Measurement of von Willebrand factor as the marker of endothelial dysfunction in vascular diseases

Beata Horvath, Dalma Hegedus, Laszlo Szapary, Zsolt Marton, Tamas Alexy, Katalin Koltai, Laszlo Czopf, Istavan Wittmann, Istvan Juricskay, Kalman Toth, Gabor Kesmarky

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Background: von Willebrand factor is a blood glycoprotein that is required for normal hemostasis. Its level can be increased by endothelial cell damage. Hypothesis: von Willebrand factor is a suitable marker of endothetial dysfunction. Methods: von Willebrand factor activity was determined by ELISA in patients with acute coronary syndromes, acute stroke and chronic vascular diseases, and was compared with the values of healthy controls. Results: von Willebrand factor activity of patients in each group was significantly higher (P<0.001) than that of the control group. The values of patients with acute coronary syndrome and acute stroke were significantly higher (P<0.05 and P<0.01, respectively) than those of patients with chronic vascular diseases. von Willebrand factor activity was significantly higher in patients with acute coronary syndrome and acute stroke (P<0.05 and P<0.01, respectively) on the sixth day than on admission. Conclusions: By measuring von Willebrand factor activity, a considerable, significant difference could be found between healthy people and chronic and acute vascular patients. The routine measurement of von Willebrand factor activity in vascular patients as an index of endothelial dysfunction may have clinical importance, because detection of this marker can be a noninvasive way of assisting diagnosis and indicating disease progression.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalExperimental and Clinical Cardiology
Volume9
Issue number1
StatePublished - Jun 24 2004

Keywords

  • Endothelial dysfunction
  • Marker
  • Vascular disorders
  • von Willebrand factor

Fingerprint Dive into the research topics of 'Measurement of von Willebrand factor as the marker of endothelial dysfunction in vascular diseases'. Together they form a unique fingerprint.

Cite this