Measurement of shear-activated platelet aggregate formation in non-anticoagulated blood: Utility in detection of clopidogrel-aspirin-induced platelet dysfunction

Gerhard J. Johnson, Anish V. Sharda, Gundu H.R. Rao, Mark H. Ereth, David D. Laxson, Whyte G. Owen

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We studied the ability of a new instrument, the PlaCor PRT that measures shear-induced platelet aggregation in fingerstick, non-anticoagulated blood without added agonists, to detect platelet dysfunction ex vivo. Platelet reactivity time (PRT) and whole blood aggregation (WBA) were measured in 160 healthy volunteers, before and after aspirin and in 170 participants with established vascular disease or risk factors thereof treated with aspirin ± clopidogrel. Pretreatment PRT and WBA were significantly correlated (collagen r = -.63; arachidonate r = -.65; P <.0001). Following aspirin, the mean PRT increased from 82 to 142 seconds (P <.0001), and in participants treated with clopidogrel-aspirin, the mean PRT (286 seconds, n = 65) was significantly longer than with aspirin alone (166 seconds, n = 105; P <.001). Only 13% of PRTs of participants treated with clopidogrel and aspirin were within the normal range. We conclude that the PlaCor PRT is a simple, rapid, point-of-care instrument that compares favorably with published descriptions of other platelet function instruments.

Original languageEnglish (US)
Pages (from-to)140-149
Number of pages10
JournalClinical and Applied Thrombosis/Hemostasis
Volume18
Issue number2
DOIs
StatePublished - Mar 1 2012

Keywords

  • aggregation
  • aspirin
  • clopidogrel
  • platelets
  • shear

Fingerprint Dive into the research topics of 'Measurement of shear-activated platelet aggregate formation in non-anticoagulated blood: Utility in detection of clopidogrel-aspirin-induced platelet dysfunction'. Together they form a unique fingerprint.

Cite this