Measurement of pulmonary artery diastolic pressure from a right ventricular pressure transducer in patients with heart failure

Peter P. Chuang; Robert F. Wilson; David C. Romans; Karen Stone; Torrey Bergman; Tom D. Bennett; Spencer H. Kubo

doi:10.1016/S1071-9164(96)80008-X

Measurement of pulmonary artery diastolic pressure from a right ventricular pressure transducer in patients with heart failure

Peter P. Chuang, Robert F. Wilson, David C. Romans, Karen Stone, Torrey Bergman, Tom D. Bennett, Spencer H. Kubo

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Recent studies have demonstrated that pulmonary artery diastolic (PAD) pressure can be measured from a transducer positioned in the right ventricle (RV) based on the finding that PAD and RV pressures are equal at the time of pulmonary valve opening, which is associated with the time of maximum positive rate of pressure development (dP/dt_max) in the ventricle. The objective of this study was to assess the correlation between estimated PAD (ePAD) pressure, obtained through a RV transducer, and actual PAD (aPAD) pressure in patients with heart failure who have abnormal hemodynamics, reduced systolic function, and variable degrees of mitral regurgitation (MR) and tricuspid regurgitation (TR). Simultaneous measurements of pulmonary artery and RV pressures were obtained with a high-fidelity Millar catheter (Millar Instruments, Houston, TX) in 10 patients with New York Heart Association class III-IV heart failure who were being evaluated for cardiac transplantation. The overall correlation between ePAD and aPAD pressures was .92 (R² = .878). This was not significantly different during the Valsalva maneuver (r = .96, R² = .943), submaximal bicycle exercise (r = .87, R² = .756), or infusions of dobutamine and nitroglycerin (r = .82, R² = .730). The overall average difference between the average ePAD (24.6 ± 7.0 mmHg) and aPAD (23.6 ± 7.0 mmHg) pressures was 1.0 ± 3.4 mmHg. The average difference between the two pressures in patients with mild to severe MR or TR was not different compared to those patients with no or trace MR or TR. The estimation of PAD pressure from an RV transducer is valid in patients with heart failure who have abnormal hemodynamics, reduced systolic function, and variable degrees of MR and TR. This correlation was observed at rest and during several provocative maneuvers. These data will be important for the development of a chronic, implantable hemodynamic monitor for patients with heart failure.

Original language	English (US)
Pages (from-to)	41-46
Number of pages	6
Journal	Journal of cardiac failure
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/S1071-9164(96)80008-X
State	Published - 1996

Bibliographical note

Funding Information:
Supported in part by a grant from Medtronic, Inc. Dr. Kubo is a consultant to Medtronic, Inc. All editorial decisions for this article, including selection of reviewers, were made by a Guest Editor. This policy applies to all articles with authors from the Universityo f Minnesota. Manuscript received Nov. 10, 1995; received in revised form Jan. 22, 1996; accepted in revised form Feb. 5, 1996. Reprint requests: Spencer H. Kubo, MD, Cardiovascular Division, Box 508 UMHC, Universityo f Minnesota, Minneapolis,M N 55455.

Keywords

Maximum rate of pressure (dP/dt)
Mitral regurgitation
Tricuspid regurgitation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/S1071-9164(96)80008-X

Find It

Find It at U of M Libraries

Cite this

@article{87ebe69ad2cf44f889fa79b65b671f20,

title = "Measurement of pulmonary artery diastolic pressure from a right ventricular pressure transducer in patients with heart failure",

abstract = "Recent studies have demonstrated that pulmonary artery diastolic (PAD) pressure can be measured from a transducer positioned in the right ventricle (RV) based on the finding that PAD and RV pressures are equal at the time of pulmonary valve opening, which is associated with the time of maximum positive rate of pressure development (dP/dtmax) in the ventricle. The objective of this study was to assess the correlation between estimated PAD (ePAD) pressure, obtained through a RV transducer, and actual PAD (aPAD) pressure in patients with heart failure who have abnormal hemodynamics, reduced systolic function, and variable degrees of mitral regurgitation (MR) and tricuspid regurgitation (TR). Simultaneous measurements of pulmonary artery and RV pressures were obtained with a high-fidelity Millar catheter (Millar Instruments, Houston, TX) in 10 patients with New York Heart Association class III-IV heart failure who were being evaluated for cardiac transplantation. The overall correlation between ePAD and aPAD pressures was .92 (R2 = .878). This was not significantly different during the Valsalva maneuver (r = .96, R2 = .943), submaximal bicycle exercise (r = .87, R2 = .756), or infusions of dobutamine and nitroglycerin (r = .82, R2 = .730). The overall average difference between the average ePAD (24.6 ± 7.0 mmHg) and aPAD (23.6 ± 7.0 mmHg) pressures was 1.0 ± 3.4 mmHg. The average difference between the two pressures in patients with mild to severe MR or TR was not different compared to those patients with no or trace MR or TR. The estimation of PAD pressure from an RV transducer is valid in patients with heart failure who have abnormal hemodynamics, reduced systolic function, and variable degrees of MR and TR. This correlation was observed at rest and during several provocative maneuvers. These data will be important for the development of a chronic, implantable hemodynamic monitor for patients with heart failure.",

keywords = "Maximum rate of pressure (dP/dt), Mitral regurgitation, Tricuspid regurgitation",

author = "Chuang, {Peter P.} and Wilson, {Robert F.} and Romans, {David C.} and Karen Stone and Torrey Bergman and Bennett, {Tom D.} and Kubo, {Spencer H.}",

note = "Funding Information: Supported in part by a grant from Medtronic, Inc. Dr. Kubo is a consultant to Medtronic, Inc. All editorial decisions for this article, including selection of reviewers, were made by a Guest Editor. This policy applies to all articles with authors from the Universityo f Minnesota. Manuscript received Nov. 10, 1995; received in revised form Jan. 22, 1996; accepted in revised form Feb. 5, 1996. Reprint requests: Spencer H. Kubo, MD, Cardiovascular Division, Box 508 UMHC, Universityo f Minnesota, Minneapolis,M N 55455.",

year = "1996",

doi = "10.1016/S1071-9164(96)80008-X",

language = "English (US)",

volume = "2",

pages = "41--46",

journal = "Journal of cardiac failure",

issn = "1071-9164",

publisher = "Churchill Livingstone",

number = "1",

}

TY - JOUR

T1 - Measurement of pulmonary artery diastolic pressure from a right ventricular pressure transducer in patients with heart failure

AU - Chuang, Peter P.

AU - Wilson, Robert F.

AU - Romans, David C.

AU - Stone, Karen

AU - Bergman, Torrey

AU - Bennett, Tom D.

AU - Kubo, Spencer H.

N1 - Funding Information: Supported in part by a grant from Medtronic, Inc. Dr. Kubo is a consultant to Medtronic, Inc. All editorial decisions for this article, including selection of reviewers, were made by a Guest Editor. This policy applies to all articles with authors from the Universityo f Minnesota. Manuscript received Nov. 10, 1995; received in revised form Jan. 22, 1996; accepted in revised form Feb. 5, 1996. Reprint requests: Spencer H. Kubo, MD, Cardiovascular Division, Box 508 UMHC, Universityo f Minnesota, Minneapolis,M N 55455.

PY - 1996

Y1 - 1996

N2 - Recent studies have demonstrated that pulmonary artery diastolic (PAD) pressure can be measured from a transducer positioned in the right ventricle (RV) based on the finding that PAD and RV pressures are equal at the time of pulmonary valve opening, which is associated with the time of maximum positive rate of pressure development (dP/dtmax) in the ventricle. The objective of this study was to assess the correlation between estimated PAD (ePAD) pressure, obtained through a RV transducer, and actual PAD (aPAD) pressure in patients with heart failure who have abnormal hemodynamics, reduced systolic function, and variable degrees of mitral regurgitation (MR) and tricuspid regurgitation (TR). Simultaneous measurements of pulmonary artery and RV pressures were obtained with a high-fidelity Millar catheter (Millar Instruments, Houston, TX) in 10 patients with New York Heart Association class III-IV heart failure who were being evaluated for cardiac transplantation. The overall correlation between ePAD and aPAD pressures was .92 (R2 = .878). This was not significantly different during the Valsalva maneuver (r = .96, R2 = .943), submaximal bicycle exercise (r = .87, R2 = .756), or infusions of dobutamine and nitroglycerin (r = .82, R2 = .730). The overall average difference between the average ePAD (24.6 ± 7.0 mmHg) and aPAD (23.6 ± 7.0 mmHg) pressures was 1.0 ± 3.4 mmHg. The average difference between the two pressures in patients with mild to severe MR or TR was not different compared to those patients with no or trace MR or TR. The estimation of PAD pressure from an RV transducer is valid in patients with heart failure who have abnormal hemodynamics, reduced systolic function, and variable degrees of MR and TR. This correlation was observed at rest and during several provocative maneuvers. These data will be important for the development of a chronic, implantable hemodynamic monitor for patients with heart failure.

AB - Recent studies have demonstrated that pulmonary artery diastolic (PAD) pressure can be measured from a transducer positioned in the right ventricle (RV) based on the finding that PAD and RV pressures are equal at the time of pulmonary valve opening, which is associated with the time of maximum positive rate of pressure development (dP/dtmax) in the ventricle. The objective of this study was to assess the correlation between estimated PAD (ePAD) pressure, obtained through a RV transducer, and actual PAD (aPAD) pressure in patients with heart failure who have abnormal hemodynamics, reduced systolic function, and variable degrees of mitral regurgitation (MR) and tricuspid regurgitation (TR). Simultaneous measurements of pulmonary artery and RV pressures were obtained with a high-fidelity Millar catheter (Millar Instruments, Houston, TX) in 10 patients with New York Heart Association class III-IV heart failure who were being evaluated for cardiac transplantation. The overall correlation between ePAD and aPAD pressures was .92 (R2 = .878). This was not significantly different during the Valsalva maneuver (r = .96, R2 = .943), submaximal bicycle exercise (r = .87, R2 = .756), or infusions of dobutamine and nitroglycerin (r = .82, R2 = .730). The overall average difference between the average ePAD (24.6 ± 7.0 mmHg) and aPAD (23.6 ± 7.0 mmHg) pressures was 1.0 ± 3.4 mmHg. The average difference between the two pressures in patients with mild to severe MR or TR was not different compared to those patients with no or trace MR or TR. The estimation of PAD pressure from an RV transducer is valid in patients with heart failure who have abnormal hemodynamics, reduced systolic function, and variable degrees of MR and TR. This correlation was observed at rest and during several provocative maneuvers. These data will be important for the development of a chronic, implantable hemodynamic monitor for patients with heart failure.

KW - Maximum rate of pressure (dP/dt)

KW - Mitral regurgitation

KW - Tricuspid regurgitation

UR - http://www.scopus.com/inward/record.url?scp=0030098381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030098381&partnerID=8YFLogxK

U2 - 10.1016/S1071-9164(96)80008-X

DO - 10.1016/S1071-9164(96)80008-X

M3 - Article

C2 - 8798104

AN - SCOPUS:0030098381

SN - 1071-9164

VL - 2

SP - 41

EP - 46

JO - Journal of cardiac failure

JF - Journal of cardiac failure

IS - 1

ER -

Measurement of pulmonary artery diastolic pressure from a right ventricular pressure transducer in patients with heart failure

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this