Measurement of peripheral blood flow in patients with peripheral artery disease: Methods and considerations

Dereck L. Salisbury, Rebecca J.L. Brown, Ulf G. Bronas, Laura N. Kirk, Diane Treat-Jacobson

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Peripheral artery disease (PAD) is a manifestation of generalized atherosclerosis which results in hemodynamic compromise of oxygen and substrate delivery to the lower extremity skeletal muscles. Hemodynamic assessments are vital in PAD diagnosis and in the evaluation of strategies aimed at treating claudication (i.e. exercise training, revascularization, and pharmacological agents). Venous occlusion plethysmography (VOP) is a century-old, non-invasive technique used to quantify limb blood flow and has been used to evaluate hemodynamic compromise in patients with PAD. However, the literature suggests a wide array of methodological variability in the measurement and analysis of limb blood flow using VOP. In this manuscript, we overview the clinical application of VOP measurement, and secondly we review the methodological variation that occurs during the measurement and analysis of VOP in healthy individuals and in patients with claudication.

Original languageEnglish (US)
Pages (from-to)163-171
Number of pages9
JournalVascular Medicine (United Kingdom)
Issue number2
StatePublished - Apr 1 2018

Bibliographical note

Publisher Copyright:
© 2018, © The Author(s) 2018.


  • blood flow
  • claudication
  • exercise
  • peripheral artery disease (PAD)
  • venous occlusion plethysmography (VOP)


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