Measurement and prediction of thermal behavior and acute assessment of injury in a pig model of renal cryosurgery

F. R. Schmidlin, C. C. Rupp, N. E. Hoffmann, J. E. Coad, D. J. Swanlund, J. C. Hulbert, J. C. Bischof

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Purpose: To analyze in vivo end temperatures and histologic injury in a standardized cryo-iceball using a porcine kidney model in order to establish the threshold temperature for tissue ablation. To evaluate the ability to predict end temperatures using a thermal finite element model. Materials and Methods: A single freeze/thaw cryolesion was created in five pig kidneys and the temperature history recorded. End temperature was calculated using a thermal finite element model. The threshold temperature for tissue injury was established by directly correlating end temperature and histologic injury. Results: Reproducible geometry and temperature profiles of the cryo-iceball were found. End temperature could be accurately predicted through thermal modeling, and correlation with histologic injury revealed a threshold temperature of -16.1°C for complete tissue ablation. Conclusion: Thermal modeling may accurately predict end temperature within a cryo-iceball. Provided threshold temperatures for tissue destruction are known, modeling may become a powerful tool in cryosurgery, improving the assessment of damage in normal and malignant tissue.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalJournal of endourology
Issue number2
StatePublished - 2001


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