Measured maternal prepregnancy anthropometry and newborn DNA methylation

Edwina H. Yeung; Weihua Guan; Sunni L. Mumford; Robert M. Silver; Cuilin Zhang; Michael Y. Tsai; Enrique F. Schisterman

doi:10.2217/epi-2018-0099

Measured maternal prepregnancy anthropometry and newborn DNA methylation

Edwina H. Yeung, Weihua Guan, Sunni L. Mumford, Robert M. Silver, Cuilin Zhang, Michael Y. Tsai, Enrique F. Schisterman

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16 Scopus citations

Abstract

AIM: We examined maternal prepregnancy anthropometry and cord blood DNA methylation.

METHODS: Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons.

RESULTS: Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10 -8). A suggestive association (p < 10 -6) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults.

CONCLUSION: While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.

Original language	English (US)
Pages (from-to)	187-198
Number of pages	12
Journal	Epigenomics
Volume	11
Issue number	2
DOIs	https://doi.org/10.2217/epi-2018-0099
State	Published - Feb 1 2019

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Publisher Copyright:
© 2019 Future Medicine Ltd.

Keywords

DNA methylation
maternal obesity
newborn
pregnancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/epi-2018-0099

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371845

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title = "Measured maternal prepregnancy anthropometry and newborn DNA methylation",

abstract = "AIM: We examined maternal prepregnancy anthropometry and cord blood DNA methylation.METHODS: Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons.RESULTS: Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10 -8). A suggestive association (p < 10 -6) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults. CONCLUSION: While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.",

keywords = "DNA methylation, maternal obesity, newborn, pregnancy",

author = "Yeung, {Edwina H.} and Weihua Guan and Mumford, {Sunni L.} and Silver, {Robert M.} and Cuilin Zhang and Tsai, {Michael Y.} and Schisterman, {Enrique F.}",

note = "Publisher Copyright: {\textcopyright} 2019 Future Medicine Ltd.",

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doi = "10.2217/epi-2018-0099",

language = "English (US)",

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T1 - Measured maternal prepregnancy anthropometry and newborn DNA methylation

AU - Yeung, Edwina H.

AU - Guan, Weihua

AU - Mumford, Sunni L.

AU - Silver, Robert M.

AU - Zhang, Cuilin

AU - Tsai, Michael Y.

AU - Schisterman, Enrique F.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - AIM: We examined maternal prepregnancy anthropometry and cord blood DNA methylation.METHODS: Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons.RESULTS: Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10 -8). A suggestive association (p < 10 -6) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults. CONCLUSION: While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.

AB - AIM: We examined maternal prepregnancy anthropometry and cord blood DNA methylation.METHODS: Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons.RESULTS: Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10 -8). A suggestive association (p < 10 -6) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults. CONCLUSION: While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.

KW - DNA methylation

KW - maternal obesity

KW - newborn

KW - pregnancy

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Measured maternal prepregnancy anthropometry and newborn DNA methylation

Abstract

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Keywords

UN SDGs

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