The measles virus genome was traced in acute and chronic infections of the central nervous system in hamsters and humans. The extent of viral replication and gene expression was assessed by the techniques of in situ hybridization and immunofluorescence. Both replication and gene expression were restricted in chronically infected hamsters and in humans with subacute sclerosing panencephalitis. It is proposed that restriction plays an important role in persistence of measles virus and the slow evolution of disease in these and other slow infections.
Bibliographical noteFunding Information:
Received for publication February 2, 1981, and in revised form April 23, 1981. This research was supported in part by funds from the National Multiple Sclerosis Society, the Public Health Service, the Veterans Administration, and the American Cancer Society. Dr. Haase is a Medical Investigator of the Veterans Administration. We thank Harriet Lukes for typing the manuscript. Please address requests for reprints to Dr. A. T. Haase, Division of Infectious Disease, V.A. Medical Center, 4150 Clement Street, San Francisco, California 94121.
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