Measles (Rubeola) susceptibility among elementary schoolchildren

Janal M. Kalis, Paul G. Quie, Henry H. Balfour

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Measles (rubeola) immunity among 479 elementary schoolchildren from suburban Minneapolis was serologically surveyed in December 1971. Of the 479 children, 25 (5.2%) had hemagglu tination-inhibition (HI) titers <2. These children were considered susceptible to measles. For the 233 immunized children with no measles history, 13 (5.6%) had rubeola HI titers <2 while 5 (5.1%) of the 98 youngsters with a history of clinical measles had rubeola HI titers <2. Of the 454 immune children, 73 (16%) had measles HI titers between 2 and 8. These findings confirm durable immunity and a low rate of vaccine failure following live attenuated measles vaccination but demonstrate the importance of testing sera beginning at a dilution of 2 in order to detect children with low antibody levels. This survey also suggests that maternal antibody interferes with the active immune response in youngsters immunized when <1 year of age because this group of children had significantly lower geometric mean titers and significantly more susceptibles than the children immunized when ≥2 years.

Original languageEnglish (US)
Pages (from-to)527-531
Number of pages5
JournalAmerican journal of epidemiology
Volume101
Issue number6
DOIs
StatePublished - Jun 1975

Keywords

  • Hemagglutination-inhibition
  • Measles
  • Rubeola
  • Vaccination

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