Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter

Gerrit Vreeman, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiting a wide range of mechanical properties, we show that the in-die Py correlates strongly with three established plasticity parameters obtained from the out-of-die Heckel analysis, Kuentz-Leuenberger analysis, and macroindentation. Thus, the in-die Py is a reliable parameter for quantifying powder plasticity in a material-sparing and expedited manner.

Original languageEnglish (US)
Article number100094
JournalInternational Journal of Pharmaceutics: X
Volume3
DOIs
StatePublished - Dec 2021

Bibliographical note

Funding Information:
Funding from the National Science Foundation through grant number IIP-1919037 is gratefully acknowledged for partially supporting G.V.

Publisher Copyright:
© 2021 The Author(s)

Keywords

  • Compaction
  • Heckel analysis
  • In-die
  • Plasticity
  • Powder

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