Recently introduced 3D radial MRI pulse sequence entitled Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) having virtually zero acquisition delay was used to obtain functional MRI (fMRI) contrast in rat's brain at 9.4 T during deep brain stimulation (DBS). The results demonstrate that MB-SWIFT allows functional images free of susceptibility artifacts, and provides an excellent fMRI activation contrast in the brain. Flip angle dependence of the MB-SWIFT fMRI signal and elimination of the fMRI contrast while using saturation bands, indicate a blood flow origin of the observed fMRI contrast. MB-SWIFT fMRI modality permits activation studies in the close proximity to an implanted lead, which is not possible to achieve with conventionally used gradient echo and spin echo - echo planar imaging fMRI techniques. We conclude that MB-SWIFT fMRI is a powerful imaging modality for investigations of functional responses during DBS.
Bibliographical noteFunding Information:
This work was supported by: the National Institutes of Health (P41 EB015894, P30 NS076408); EU H2020 RISE MICROBRADAM, Professor Pool; WM KECK Foundation; MnDRIVE and The Emil Aaltonen Foundation post-doctoral fellowships to LJL. The authors are grateful to Prof. Kamil Ugurbil for stimulating discussions and comments on the manuscript.
© 2017 The Authors
Copyright 2018 Elsevier B.V., All rights reserved.
- Blood flow
- Deep brain stimulation
- Multi-band SWIFT
- Zero-TE fMRI