Maximum-likelihood estimation of familial correlations from multivariate quantitative data on pedigrees: A general method and examples

D. C. Rao, G. P. Vogler, M. McGue, J. M. Russell

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

A general method for maximum-likelihood estimation of familial correlations from pedigree data is presented. The method is applicable to any type of data structure, including pedigrees in which variable numbers of individuals are present within classes of relatives, data in which multiple phenotypic measures are obtained on each individual, and multiple group analyses in which some correlations are equated acrosss groups. The method is applied to data on high-density lipoprotein cholesterol and total cholesterol levels obtained from participants in the Swedish Twin Family Study. Results indicate that there is strong familial resemblance for both traits but little cross-trait resemblance.

Original languageEnglish (US)
Pages (from-to)1104-1116
Number of pages13
JournalAmerican Journal of Human Genetics
Volume41
Issue number6
StatePublished - 1987

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