Maxillary sinus augmentation using a peptide-modified graft material in three mixtures: A prospective human case series of histologic and histomorphometric results

Michael Gelbart, Robert Friedman, Vasile Burlui, Michael D Rohrer, Brent Atkinson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

This prospective study assessed vital bone quality and quantity after grafting maxillary sinuses with anorganic bone mineral containing a cell binding peptide (ABM/P-15) in combination with DFDBA (Mix I), hydrogel/ABM/P-15 (Mix II), or PRP (Mix III). Fifteen maxillary sinuses in 12 patients were grafted with the ABM/P-15 mixtures and after 4 to 5 months, cores were taken and analyzed histologically and histomorphometrically. Fifty-nine screw-type implants were placed. Mixes containing a spacer material (Mix I and II) produced greater average vital bone, more mature bone, and more interconnected bone bridges from the cortical (oral) end to the most apical portion, compared to a mix that lacked a spacer material (Mix III). None of the 59 implants failed with any graft material up to 5 months following implant placement. The study demonstrates that new trabecular bone is formed after grafting ABM/P-15 in the sinus floor; that more vital bone is formed when ABM/P-15 is mixed with a spacer material than without; and that implants can be successfully placed.

Original languageEnglish (US)
Pages (from-to)185-193
Number of pages9
JournalImplant Dentistry
Volume14
Issue number2
DOIs
StatePublished - Jun 1 2005

Keywords

  • Anorganic bone matrix
  • Dental implants
  • Histomorphometry
  • Human maxillary bone regeneration

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