TY - JOUR
T1 - Maxillary sinus augmentation using a peptide-modified graft material in three mixtures
T2 - A prospective human case series of histologic and histomorphometric results
AU - Gelbart, Michael
AU - Friedman, Robert
AU - Burlui, Vasile
AU - Rohrer, Michael D
AU - Atkinson, Brent
PY - 2005/6/1
Y1 - 2005/6/1
N2 - This prospective study assessed vital bone quality and quantity after grafting maxillary sinuses with anorganic bone mineral containing a cell binding peptide (ABM/P-15) in combination with DFDBA (Mix I), hydrogel/ABM/P-15 (Mix II), or PRP (Mix III). Fifteen maxillary sinuses in 12 patients were grafted with the ABM/P-15 mixtures and after 4 to 5 months, cores were taken and analyzed histologically and histomorphometrically. Fifty-nine screw-type implants were placed. Mixes containing a spacer material (Mix I and II) produced greater average vital bone, more mature bone, and more interconnected bone bridges from the cortical (oral) end to the most apical portion, compared to a mix that lacked a spacer material (Mix III). None of the 59 implants failed with any graft material up to 5 months following implant placement. The study demonstrates that new trabecular bone is formed after grafting ABM/P-15 in the sinus floor; that more vital bone is formed when ABM/P-15 is mixed with a spacer material than without; and that implants can be successfully placed.
AB - This prospective study assessed vital bone quality and quantity after grafting maxillary sinuses with anorganic bone mineral containing a cell binding peptide (ABM/P-15) in combination with DFDBA (Mix I), hydrogel/ABM/P-15 (Mix II), or PRP (Mix III). Fifteen maxillary sinuses in 12 patients were grafted with the ABM/P-15 mixtures and after 4 to 5 months, cores were taken and analyzed histologically and histomorphometrically. Fifty-nine screw-type implants were placed. Mixes containing a spacer material (Mix I and II) produced greater average vital bone, more mature bone, and more interconnected bone bridges from the cortical (oral) end to the most apical portion, compared to a mix that lacked a spacer material (Mix III). None of the 59 implants failed with any graft material up to 5 months following implant placement. The study demonstrates that new trabecular bone is formed after grafting ABM/P-15 in the sinus floor; that more vital bone is formed when ABM/P-15 is mixed with a spacer material than without; and that implants can be successfully placed.
KW - Anorganic bone matrix
KW - Dental implants
KW - Histomorphometry
KW - Human maxillary bone regeneration
UR - http://www.scopus.com/inward/record.url?scp=21344441020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21344441020&partnerID=8YFLogxK
U2 - 10.1097/01.id.0000165029.86196.27
DO - 10.1097/01.id.0000165029.86196.27
M3 - Article
C2 - 15968191
AN - SCOPUS:21344441020
SN - 1056-6163
VL - 14
SP - 185
EP - 193
JO - The International journal of oral implantology : implantologist
JF - The International journal of oral implantology : implantologist
IS - 2
ER -