Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes

Fikru B Bedada, Matthew Wheelwright, Joseph M Metzger

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Human heart failure due to myocardial infarction is a major health concern. The paucity of organs for transplantation limits curative approaches for the diseased and failing adult heart. Human induced pluripotent stem cell-derived cardiac myocytes (hiPSC-CMs) have the potential to provide a long-term, viable, regenerative-medicine alternative. Significant progress has been made with regard to efficient cardiac myocyte generation from hiPSCs. However, directing hiPSC-CMs to acquire the physiological structure, gene expression profile and function akin to mature cardiac tissue remains a major obstacle. Thus, hiPSC-CMs have several hurdles to overcome before they find their way into translational medicine. In this review, we address the progress that has been made, the void in knowledge and the challenges that remain. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.

Original languageEnglish (US)
Pages (from-to)1829-1838
Number of pages10
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1863
Issue number7
DOIs
StatePublished - Jul 1 2016

Bibliographical note

Funding Information:
This work is supported by NIH HL 1000407 .

Publisher Copyright:
© 2015 The Authors.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Differentiation
  • Heart
  • Maturation
  • Stem cells
  • Troponin

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