Matrix nanotopography as a regulator of cell function

Deok Ho Kim, Paolo P. Provenzano, Chris L. Smith, Andre Levchenko

Research output: Contribution to journalReview articlepeer-review

395 Scopus citations

Abstract

The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial and mechanical cues to which cells respond. In addition to soluble chemical factors, physical interactions between the cell and ECM regulate primary cell processes, including differentiation, migration, and proliferation. Advances in microtechnology and, more recently, nanotechnology provide a powerful means to study the influence of the ECM on cell behavior. By recapitulating local architectures that cells encounter in vivo, we can elucidate and dissect the fundamental signal transduction pathways that control cell behavior in critical developmental, physiological, and pathological processes.

Original languageEnglish (US)
Pages (from-to)351-360
Number of pages10
JournalJournal of Cell Biology
Volume197
Issue number3
DOIs
StatePublished - Apr 2012

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