Matrix nanotopography as a regulator of cell function

Deok Ho Kim, Paolo P. Provenzano, Chris L. Smith, Andre Levchenko

Research output: Contribution to journalReview article

326 Citations (Scopus)

Abstract

The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial and mechanical cues to which cells respond. In addition to soluble chemical factors, physical interactions between the cell and ECM regulate primary cell processes, including differentiation, migration, and proliferation. Advances in microtechnology and, more recently, nanotechnology provide a powerful means to study the influence of the ECM on cell behavior. By recapitulating local architectures that cells encounter in vivo, we can elucidate and dissect the fundamental signal transduction pathways that control cell behavior in critical developmental, physiological, and pathological processes.

Original languageEnglish (US)
Pages (from-to)351-360
Number of pages10
JournalJournal of Cell Biology
Volume197
Issue number3
DOIs
StatePublished - Apr 1 2012

Fingerprint

Extracellular Matrix
Microtechnology
Physiological Phenomena
Nanotechnology
Behavior Control
Pathologic Processes
Cell Communication
Cues
Signal Transduction

Cite this

Matrix nanotopography as a regulator of cell function. / Kim, Deok Ho; Provenzano, Paolo P.; Smith, Chris L.; Levchenko, Andre.

In: Journal of Cell Biology, Vol. 197, No. 3, 01.04.2012, p. 351-360.

Research output: Contribution to journalReview article

Kim, Deok Ho ; Provenzano, Paolo P. ; Smith, Chris L. ; Levchenko, Andre. / Matrix nanotopography as a regulator of cell function. In: Journal of Cell Biology. 2012 ; Vol. 197, No. 3. pp. 351-360.
@article{9dd8e7d7bfdc45c4bff2b7b04a885119,
title = "Matrix nanotopography as a regulator of cell function",
abstract = "The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial and mechanical cues to which cells respond. In addition to soluble chemical factors, physical interactions between the cell and ECM regulate primary cell processes, including differentiation, migration, and proliferation. Advances in microtechnology and, more recently, nanotechnology provide a powerful means to study the influence of the ECM on cell behavior. By recapitulating local architectures that cells encounter in vivo, we can elucidate and dissect the fundamental signal transduction pathways that control cell behavior in critical developmental, physiological, and pathological processes.",
author = "Kim, {Deok Ho} and Provenzano, {Paolo P.} and Smith, {Chris L.} and Andre Levchenko",
year = "2012",
month = "4",
day = "1",
doi = "10.1083/jcb.201108062",
language = "English (US)",
volume = "197",
pages = "351--360",
journal = "Journal of Cell Biology",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "3",

}

TY - JOUR

T1 - Matrix nanotopography as a regulator of cell function

AU - Kim, Deok Ho

AU - Provenzano, Paolo P.

AU - Smith, Chris L.

AU - Levchenko, Andre

PY - 2012/4/1

Y1 - 2012/4/1

N2 - The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial and mechanical cues to which cells respond. In addition to soluble chemical factors, physical interactions between the cell and ECM regulate primary cell processes, including differentiation, migration, and proliferation. Advances in microtechnology and, more recently, nanotechnology provide a powerful means to study the influence of the ECM on cell behavior. By recapitulating local architectures that cells encounter in vivo, we can elucidate and dissect the fundamental signal transduction pathways that control cell behavior in critical developmental, physiological, and pathological processes.

AB - The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial and mechanical cues to which cells respond. In addition to soluble chemical factors, physical interactions between the cell and ECM regulate primary cell processes, including differentiation, migration, and proliferation. Advances in microtechnology and, more recently, nanotechnology provide a powerful means to study the influence of the ECM on cell behavior. By recapitulating local architectures that cells encounter in vivo, we can elucidate and dissect the fundamental signal transduction pathways that control cell behavior in critical developmental, physiological, and pathological processes.

UR - http://www.scopus.com/inward/record.url?scp=84862621219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862621219&partnerID=8YFLogxK

U2 - 10.1083/jcb.201108062

DO - 10.1083/jcb.201108062

M3 - Review article

VL - 197

SP - 351

EP - 360

JO - Journal of Cell Biology

JF - Journal of Cell Biology

SN - 0021-9525

IS - 3

ER -