TY - JOUR
T1 - Mathematical modelling of COVID-19 transmission dynamics in a partially comorbid community
AU - Ssebuliba, J.
AU - Nakakawa, J. N.
AU - Ssematimba, A.
AU - Mugisha, J. Y.T.
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2022/6
Y1 - 2022/6
N2 - A deterministic S,Em,Ec,Im,Ic,H,R epidemic model that describes the spreading of SARS-COV-2 within a community with comorbidities is formulated. Size dependent area is incorporated into the model to quantify the effect of social distancing and the results indicate that the risk of community transmission is optimally minimised when the occupancy area is increased. The reproduction number is shown to have a positive relationship with the infection rate, the proportion of individuals with comorbidities and the proportion of susceptible individuals adhering to standard operating procedures. The model exhibits a unique endemic equilibrium whose stability largely depends on the rate of hospitalisation of individuals with underlying health conditions (ωm) as compared to those without these conditions (ωc), such that stability is guaranteed if ωm<ωc. Furthermore, if individuals with comorbidities effectively report for treatment and hospitalisation at a rate of 0.5 per day, the epidemic curve peaks 3-fold higher among people with comorbidities. The infection peaks are delayed if the area occupied by community is increased. In conclusion, we observed that community infections increase significantly with decreasing detection rates for both individuals with or without comorbidities.
AB - A deterministic S,Em,Ec,Im,Ic,H,R epidemic model that describes the spreading of SARS-COV-2 within a community with comorbidities is formulated. Size dependent area is incorporated into the model to quantify the effect of social distancing and the results indicate that the risk of community transmission is optimally minimised when the occupancy area is increased. The reproduction number is shown to have a positive relationship with the infection rate, the proportion of individuals with comorbidities and the proportion of susceptible individuals adhering to standard operating procedures. The model exhibits a unique endemic equilibrium whose stability largely depends on the rate of hospitalisation of individuals with underlying health conditions (ωm) as compared to those without these conditions (ωc), such that stability is guaranteed if ωm<ωc. Furthermore, if individuals with comorbidities effectively report for treatment and hospitalisation at a rate of 0.5 per day, the epidemic curve peaks 3-fold higher among people with comorbidities. The infection peaks are delayed if the area occupied by community is increased. In conclusion, we observed that community infections increase significantly with decreasing detection rates for both individuals with or without comorbidities.
KW - COVID-19
KW - Community transmission
KW - Comorbidity
KW - Mathematical modelling
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U2 - 10.1016/j.padiff.2021.100212
DO - 10.1016/j.padiff.2021.100212
M3 - Article
AN - SCOPUS:85122940864
SN - 2666-8181
VL - 5
JO - Partial Differential Equations in Applied Mathematics
JF - Partial Differential Equations in Applied Mathematics
M1 - 100212
ER -