Abstract
The blood glucose and plasma insulin responses during slow intravenous infusion of insulin in six normal and seven diabetic subjects were fitted to a previously described model utilizing four first-order rate constants for the glucose-insulin interactions. Certain lumped parameters of the model were shown to be characteristic of the subjects' responses and abnormalities. The predicted values of blood glucose and plasma insulin can be made to approximate the actual measurement in all subjects. Additional studies are proposed to delineate further the range of applicability of the model and to characterize diabetic instability.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 71-78 |
| Number of pages | 8 |
| Journal | Computers in Biology and Medicine |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1973 |
| Externally published | Yes |
Bibliographical note
Funding Information:*From the Mayo Clinic and Mayo Foundation, Rochester, Minnesota (Drs. Yipintsoi, Molnar, Service and Miss Spivak), and from the division of Health Computer Sciences, University of Minnesota, Minneapolis, Minnesota (Drs. Gatewood, Ackerman and Rosevear). tThis investigation was supported in part by Research Grants HL-43128, RR-7, and RR-267 from the National Institutes of Health. Dr. Yipintsoi was the recipient of Special Fellowship Award HL-43128 from the National Institutes of Health.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Blood glucose
- Computer simulation
- Diabetes
- Insulin infusion
- Mathematical model
- Optimizing search routine
- Plasma insulin
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