Maternal vitamin and iron supplementation and risk of infant leukaemia: A report from the Children's Oncology Group

A. M. Linabery, S. E. Puumala, J. M. Hilden, S. M. Davies, N. A. Heerema, M. A. Roesler, J. A. Ross

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Prenatal supplementation has been inversely associated with childhood, but not with infant, leukaemia. Methods: Mothers of 443 cases of infant leukaemia diagnosed during 1996-2006 and 324 frequency-matched controls completed interviews. Associations were evaluated by unconditional logistic regression. Results : We observed no associations between prenatal vitamin (odds ratio (OR)0.79, 95% confidence interval (CI): 0.44-1.42) or iron supplementation (OR1.07, 95% CI: 0.75-1.52) and infant leukaemia after adjustment for race/ethnicity and income. Similar results were observed for leukaemia subtypes analysed separately.ConclusionThe observed null associations may be attributable to high supplementation rates and/or national fortification programmes.

Original languageEnglish (US)
Pages (from-to)1724-1728
Number of pages5
JournalBritish Journal of Cancer
Volume103
Issue number11
DOIs
StatePublished - Nov 23 2010

Bibliographical note

Funding Information:
This research was supported by the National Institutes of Health Grants R01 CA79940, T32 CA99936, U10 CA13539, and U10 CA98543; Grant P30 CA77588 (University of Minnesota Masonic Cancer Center shared resource: Health Survey Research Center); and the Children’s Cancer Research Fund, Minneapolis, MN, USA.

Keywords

  • epidemiology
  • infants
  • leukaemia
  • vitamin

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