Maternal Proinflammatory Adipokines throughout Pregnancy and Neonatal Size and Body Composition: A Prospective Study

Ellen C. Francis, Mengying Li, Stefanie N. Hinkle, Jinbo Chen, Jing Wu, Yeyi Zhu, Haiming Cao, Michael Y. Tsai, Liwei Chen, Cuilin Zhang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Increased maternal adiposity and inflammation have impacts on fetal growth. Objectives: The purpose of this prospective study was to investigate the associations of 3 proinflammatory adipokines in pregnancy with neonatal anthropometry. Methods: In a sample of 321 US pregnant women from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singleton Cohort (NCT00912132), plasma IL-6, fatty acid binding protein-4 (FABP4), and chemerin were measured in plasma samples collected at 10-14, 15-26, 23-31, and 33-39 weeks of gestation. Generalized linear models were used to estimate associations of adipokines with neonatal weight, thigh, and crown-heel length, and skinfolds at birth. Models adjusted for age, race/ethnicity, education, nulliparity, prepregnancy BMI, and weeks of gestation at blood collection. Results: At each time point, higher IL-6 was associated with lower neonatal birthweight and thigh length. At 15-26 weeks of gestation, a 1 SD pg/mL increase in IL-6 was associated with-84.46 g lower neonatal birthweight (95% CI:-150.70,-18.22),-0.17 cm shorter thigh length (95% CI:-0.27,-0.07),-0.43 cm shorter crown-heel length (95% CI:-0.75,-0.10), and-0.75 mm smaller sum of skinfolds (95% CI:-1.19,-0.31), with similar associations at 23-31 and 33-39 weeks of gestation. There were no associations of FABP4 and chemerin with neonatal anthropometry. Conclusions: Starting as early as 15 weeks of gestation, higher maternal IL-6 concentrations in pregnancy were associated with lower neonatal birthweight, thigh and crown-heel length, and skinfolds. These data provide insight into the relevance of maternal inflammatory markers with neonatal anthropometry.

Original languageEnglish (US)
Article numbernzab113
JournalCurrent Developments in Nutrition
Volume5
Issue number10
DOIs
StatePublished - Oct 1 2021

Bibliographical note

Publisher Copyright:
© 2021 Published by Oxford University Press on behalf of the American Society for Nutrition 2021.

Keywords

  • adipokines
  • inflammation
  • interleukin 6
  • offspring body composition
  • pregnancy

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