Maternal prenatal cigarette, alcohol and illicit drug use and risk of infant leukaemia: A report from the Children's Oncology Group

Megan E. Slater, Amy M. Linabery, Cindy K. Blair, Logan G. Spector, Nyla A. Heerema, Leslie L. Robison, Julie A. Ross

Research output: Contribution to journalArticle

Abstract

Several case-control studies have evaluated associations between maternal smoking, alcohol consumption and illicit drug use during pregnancy and risk of childhood leukaemia. Few studies have specifically focused on infants (1 cigarette/day) and illicit drug use (any amount) before and/or during pregnancy were not significantly associated with infant leukaemia. Alcohol use (>1 drink/week) during pregnancy was inversely associated with infant leukaemia overall [OR = 0.64; 95% CI 0.43, 0.94], AML [OR = 0.49; 95% CI 0.28, 0.87], and leukaemia with mixed lineage leukaemia gene rearrangements ('MLL+') [OR = 0.59; 95% CI 0.36, 0.97]. While our results agree with the fairly consistent evidence that maternal cigarette smoking is not associated with childhood leukaemia, the data regarding alcohol and illicit drug use are not consistent with prior reports and are difficult to interpret. It is possible that unhealthy maternal behaviours during pregnancy, some of which carry potential legal consequences, may not be adequately measured using only self-report. Future case-control studies of childhood leukaemia that pursue these exposures may benefit from incorporation of validated instruments and/or biomarkers when feasible.
Original languageEnglish (US)
Pages (from-to)559-565
Number of pages6
JournalPaediatric and Perinatal Epidemiology
Volume25
Issue number6
StatePublished - 2011

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Street Drugs
Tobacco Products
Leukemia
Alcohols
Mothers
Pregnancy
Case-Control Studies
Smoking
Maternal Behavior
Gene Rearrangement
Alcohol Drinking
Self Report
Biomarkers

Keywords

  • childhood cancer
  • illicit drug use
  • infant leukaemia
  • maternal alcohol
  • maternal smoking

Cite this

Maternal prenatal cigarette, alcohol and illicit drug use and risk of infant leukaemia: A report from the Children's Oncology Group. / Slater, Megan E.; Linabery, Amy M.; Blair, Cindy K.; Spector, Logan G.; Heerema, Nyla A.; Robison, Leslie L.; Ross, Julie A.

In: Paediatric and Perinatal Epidemiology, Vol. 25, No. 6, 2011, p. 559-565.

Research output: Contribution to journalArticle

Slater, Megan E. ; Linabery, Amy M. ; Blair, Cindy K. ; Spector, Logan G. ; Heerema, Nyla A. ; Robison, Leslie L. ; Ross, Julie A. / Maternal prenatal cigarette, alcohol and illicit drug use and risk of infant leukaemia: A report from the Children's Oncology Group. In: Paediatric and Perinatal Epidemiology. 2011 ; Vol. 25, No. 6. pp. 559-565.
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abstract = "Several case-control studies have evaluated associations between maternal smoking, alcohol consumption and illicit drug use during pregnancy and risk of childhood leukaemia. Few studies have specifically focused on infants (1 cigarette/day) and illicit drug use (any amount) before and/or during pregnancy were not significantly associated with infant leukaemia. Alcohol use (>1 drink/week) during pregnancy was inversely associated with infant leukaemia overall [OR = 0.64; 95{\%} CI 0.43, 0.94], AML [OR = 0.49; 95{\%} CI 0.28, 0.87], and leukaemia with mixed lineage leukaemia gene rearrangements ('MLL+') [OR = 0.59; 95{\%} CI 0.36, 0.97]. While our results agree with the fairly consistent evidence that maternal cigarette smoking is not associated with childhood leukaemia, the data regarding alcohol and illicit drug use are not consistent with prior reports and are difficult to interpret. It is possible that unhealthy maternal behaviours during pregnancy, some of which carry potential legal consequences, may not be adequately measured using only self-report. Future case-control studies of childhood leukaemia that pursue these exposures may benefit from incorporation of validated instruments and/or biomarkers when feasible.",
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AU - Spector, Logan G.

AU - Heerema, Nyla A.

AU - Robison, Leslie L.

AU - Ross, Julie A.

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AB - Several case-control studies have evaluated associations between maternal smoking, alcohol consumption and illicit drug use during pregnancy and risk of childhood leukaemia. Few studies have specifically focused on infants (1 cigarette/day) and illicit drug use (any amount) before and/or during pregnancy were not significantly associated with infant leukaemia. Alcohol use (>1 drink/week) during pregnancy was inversely associated with infant leukaemia overall [OR = 0.64; 95% CI 0.43, 0.94], AML [OR = 0.49; 95% CI 0.28, 0.87], and leukaemia with mixed lineage leukaemia gene rearrangements ('MLL+') [OR = 0.59; 95% CI 0.36, 0.97]. While our results agree with the fairly consistent evidence that maternal cigarette smoking is not associated with childhood leukaemia, the data regarding alcohol and illicit drug use are not consistent with prior reports and are difficult to interpret. It is possible that unhealthy maternal behaviours during pregnancy, some of which carry potential legal consequences, may not be adequately measured using only self-report. Future case-control studies of childhood leukaemia that pursue these exposures may benefit from incorporation of validated instruments and/or biomarkers when feasible.

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