Abstract
Background: Hepatoblastoma is a rare childhood liver cancer with an obscure etiology, however it is potentially associated with selected pregnancy events and hepatoblastoma risk in offspring. Methods: Adjusted unconditional logistic regression estimated odds ratios (OR) and corresponding 95% confidence intervals (CI) for self-reported pregnancy events and medication use in a sample of mothers of 383 childhood hepatoblastoma cases and 387 controls. Results: Risk of hepatoblastoma was significantly associated with maternal first trimester weight gain (OR. =. 1.02; 95% CI 1.00, 1.04 per 1. lb increase and nearly significantly with maternal multivitamin use (OR. =. 0.73; 95% CI 0.51, 1.03). Hepatoblastoma was not associated with other maternal weight changes, maternal illness or medication use during pregnancy. Conclusion: We found little evidence that maternal illness or most medication use during pregnancy are associated with hepatoblastoma in offspring.
Original language | English (US) |
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Pages (from-to) | 318-320 |
Number of pages | 3 |
Journal | Cancer Epidemiology |
Volume | 37 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2013 |
Keywords
- Body weight changes
- Case-control studies
- Hepatoblastoma
- Pregnancy complications
- Self medication