Maternal pregnancy events and exposures and risk of hepatoblastoma: A Children's Oncology Group (COG) study

Jessica R B Musselman, Michael K. Georgieff, Julie A. Ross, Gail E. Tomlinson, James Feusner, Mark Krailo, Logan G. Spector

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: Hepatoblastoma is a rare childhood liver cancer with an obscure etiology, however it is potentially associated with selected pregnancy events and hepatoblastoma risk in offspring. Methods: Adjusted unconditional logistic regression estimated odds ratios (OR) and corresponding 95% confidence intervals (CI) for self-reported pregnancy events and medication use in a sample of mothers of 383 childhood hepatoblastoma cases and 387 controls. Results: Risk of hepatoblastoma was significantly associated with maternal first trimester weight gain (OR. =. 1.02; 95% CI 1.00, 1.04 per 1. lb increase and nearly significantly with maternal multivitamin use (OR. =. 0.73; 95% CI 0.51, 1.03). Hepatoblastoma was not associated with other maternal weight changes, maternal illness or medication use during pregnancy. Conclusion: We found little evidence that maternal illness or most medication use during pregnancy are associated with hepatoblastoma in offspring.

Original languageEnglish (US)
Pages (from-to)318-320
Number of pages3
JournalCancer Epidemiology
Volume37
Issue number3
DOIs
StatePublished - Jun 1 2013

Keywords

  • Body weight changes
  • Case-control studies
  • Hepatoblastoma
  • Pregnancy complications
  • Self medication

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