Maternal Preeclampsia and Risk for Cardiovascular Disease in Offspring

Guadalupe Herrera-Garcia, Stephen Contag

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Hypertensive disease of pregnancy (HDP) has been associated with elevated lifetime cardiovascular risk, including stroke, myocardial disease, coronary artery disease, and peripheral arterial disease. These two entities share common risk factors such as obesity, insulin resistance, diabetes, and hypertension. This article will evaluate the current literature on the maternal and fetal cardiovascular risks posed by HDP. The landmark study by Barker et al. demonstrated increased cardiovascular risk in growth-restricted infants, which may also be associated with HDP. Research has demonstrated the effects that HDP may have on the vascular and nephron development in offspring, particularly with respect to endothelial and inflammatory markers. In order to control for confounding variables and better understand the relationship between HDP and lifetime cardiovascular risk, future research will require following blood pressure and metabolic profiles of the parturients and their offspring.

Original languageEnglish (US)
Article number475
Pages (from-to)1-10
Number of pages10
JournalCurrent Hypertension Reports
Volume16
Issue number9
DOIs
StatePublished - Sep 1 2014

Bibliographical note

Publisher Copyright:
© 2014, Springer Science+Business Media New York.

Keywords

  • Cardiovascular disease
  • Cardiovascular risk
  • Gestational hypertension
  • Hypertensive disease in pregnancy
  • Metabolic syndrome
  • Offspring
  • Preeclampsia

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