Maternal HIV-1 RNA serum levels at delivery and vertical transmission in Uganda

J. Brooks Jackson, David Horn, Estelle Piwowar, Christopher Ndugwa, Peter Kataaha, Lawrence Marum, Laura Quay

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objective. To evaluate the clinical utility of maternal HIV-1 RNA serum levels at delivery in predicting the rate of HIV-1 vertical transmission. Design and Methods. HIV-1 RNA levels were determined by the Roche Amplicor Monitor assay in serum specimens collected at the time of delivery from 94 transmitting and 107 nontransmitting infected mothers and 12 seronegative mothers in Uganda. Nonparametric Wilcoxon-Rank sum tests were used to identify significant differences in medians and RNA level distributions by transmission status. Results. Mean HIV-1 RNA copies/mL for transmitters was 3419 ± 7489 copies/mL versus 2483 ± 8954 copies/mL for nontransmitters. There was a significant difference in medians and HIV-1 RNA serum level distributions between transmitting and nontransmitting mothers (p = 0.0039). However, the predictive value for any given HIV-1 RNA level for HIV-1 vertical transmission was poor. Conclusion. Maternal HIV-1 RNA serum levels at delivery are significantly higher in transmitting mothers versus nontransmitting mothers, but appear to be of limited value in predicting HIV- 1 vertical transmission using the Roche Amplicor Monitor assay in Uganda.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalPediatric AIDS and HIV Infection
Volume7
Issue number1
StatePublished - 1996

Fingerprint Dive into the research topics of 'Maternal HIV-1 RNA serum levels at delivery and vertical transmission in Uganda'. Together they form a unique fingerprint.

  • Cite this

    Brooks Jackson, J., Horn, D., Piwowar, E., Ndugwa, C., Kataaha, P., Marum, L., & Quay, L. (1996). Maternal HIV-1 RNA serum levels at delivery and vertical transmission in Uganda. Pediatric AIDS and HIV Infection, 7(1), 37-42.