TY - JOUR
T1 - Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring
AU - the BIS Investigator Group
AU - the J. Craig Venter Institute
AU - Vuillermin, Peter J.
AU - O’Hely, Martin
AU - Collier, Fiona
AU - Allen, Katrina J.
AU - Tang, Mimi L.K.
AU - Harrison, Leonard C.
AU - Carlin, John B.
AU - Saffery, Richard
AU - Ranganathan, Sarath
AU - Sly, Peter D.
AU - Gray, Lawrence
AU - Molloy, John
AU - Pezic, Angela
AU - Conlon, Michael
AU - Topping, David
AU - Nelson, Karen
AU - Mackay, Charles R.
AU - Macia, Laurence
AU - Koplin, Jennifer
AU - Dawson, Samantha L.
AU - Moreno-Betancur, Margarita
AU - Ponsonby, Anne Louise
AU - Vashee, Sanjay
AU - Torralba, Manolito
AU - Gomez, Andres
AU - Dwyer, Terrence
AU - Burgner, David
AU - Forrester, Michael
AU - Symeonides, Christos
AU - Bandala Sanchez, Esther
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/3/24
Y1 - 2020/3/24
N2 - In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of allergic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus that produces short chain fatty acids and endotoxins, each of which may promote the development of fetal immune tolerance. In this study, we use a prebirth cohort (n = 1064 mothers) to conduct a nested case-cohort study comparing 58 mothers of babies with clinically proven food IgE mediated food allergy with 258 randomly selected mothers. Analysis of the V4 region of the 16S rRNA gene in fecal samples shows maternal carriage of Prevotella copri during pregnancy strongly predicts the absence of food allergy in the offspring. This association was confirmed using targeted qPCR and was independent of infant carriage of P. copri. Larger household size, which is a well-established protective factor for allergic disease, strongly predicts maternal carriage of P. copri.
AB - In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of allergic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus that produces short chain fatty acids and endotoxins, each of which may promote the development of fetal immune tolerance. In this study, we use a prebirth cohort (n = 1064 mothers) to conduct a nested case-cohort study comparing 58 mothers of babies with clinically proven food IgE mediated food allergy with 258 randomly selected mothers. Analysis of the V4 region of the 16S rRNA gene in fecal samples shows maternal carriage of Prevotella copri during pregnancy strongly predicts the absence of food allergy in the offspring. This association was confirmed using targeted qPCR and was independent of infant carriage of P. copri. Larger household size, which is a well-established protective factor for allergic disease, strongly predicts maternal carriage of P. copri.
KW - Anti-Bacterial Agents/pharmacology
KW - Diet
KW - Family Characteristics
KW - Feces/microbiology
KW - Female
KW - Food Hypersensitivity/microbiology
KW - Humans
KW - Infant
KW - Microbiota/drug effects
KW - Mothers
KW - Pregnancy
KW - Prevotella/physiology
KW - Risk Factors
UR - https://www.scopus.com/pages/publications/85082438238
UR - https://www.scopus.com/pages/publications/85082438238#tab=citedBy
U2 - 10.1038/s41467-020-14552-1
DO - 10.1038/s41467-020-14552-1
M3 - Article
C2 - 32210229
AN - SCOPUS:85082438238
SN - 2041-1723
VL - 11
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 1452
ER -