Massively parallel, computationally guided design of a proenzyme

Keyphrases

• Massively Parallel 100%
• Guide Design 100%
• Proenzymes 100%
• Proteolysis 66%
• Prodomain 66%
• Cell Culture 33%
• Computational Design 33%
• Cancer Treatment 33%
• Domain-independent 33%
• Type-specific 33%
• Protease 33%
• Microenvironment 33%
• Drug Toxicity 33%
• Zymogen 33%
• Stimuli-responsive 33%
• Next-generation Sequencing 33%
• Kinetic Characterization 33%
• Incubation 33%
• Structural Characterization 33%
• Catalytic Domain 33%
• Disulfide 33%
• Inhibition Mechanism 33%
• Disulfide Bond 33%
• Design Model 33%
• Designed Proteins 33%
• Therapeutic Action 33%
• Binding Mechanism 33%
• Thermodynamic Characterization 33%
• Detailed Chemical Kinetics 33%
• Natural Enzymes 33%
• Off-target Effects 33%
• Degree of Inhibition 33%
• Design Screening 33%
• Carboxypeptidase G2 33%
• Low Activity 33%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Protein Catabolism 40%
• Zymogen 20%
• Disulfide 20%
• Next Generation Sequencing 20%
• Disulfide Bond 20%
• Cell Culture 20%
• Enzyme Active Site 20%
• Drug Toxicity 20%
• Carboxypeptidase 20%
• Protease 20%