Massive splenomegaly and Epstein-Barr virus - Associated infectious mononucleosis in a patient with Gaucher disease

Mary Eapen, Margaret Hostetter, Joseph P Neglia

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Purpose: Gaucher disease should be considered in the differential diagnosis of a patient with Epstein-Barr virus (EBV) infection who has unexplained or disproportionate splenomegaly. Patients and Methods: A previously asymptomatic adolescent with EBV-associated infectious mononucleosis and massive splenomegaly is described. He was found to have Gaucher disease on bone marrow biopsy, which was performed to exclude a hematologic malignancy. The diagnosis was confirmed by assay of β- glucosidase enzyme activity. Results: Regression of splenomegaly and improving hematologic indices. Conclusion: Patients with infectious mononucleosis and disproportionate organomegaly should be investigated to exclude a hematologic malignancy or an underlying storage disorder such as Gaucher disease.

Original languageEnglish (US)
Pages (from-to)47-49
Number of pages3
JournalJournal of pediatric hematology/oncology
Volume21
Issue number1
DOIs
StatePublished - Jan 1 1999

Keywords

  • Gaucher disease
  • Infectious mononucleosis
  • Massive splenomegaly

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