Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of N′-Nitrosonornicotine (NNN) in the Rat

Keyphrases

• Mass Spectrometry 100%
• Metabolic Profiling 100%
• Urinary Metabolites 100%
• N'-nitrosonornicotine 100%
• Metabolic Activation 15%
• Liquid Chromatography-high Resolution Mass Spectrometry (LC-HRMS) 10%
• Oxides 5%
• Potential Biomarkers 5%
• N-nitrosamines 5%
• Cysteine 5%
• Targeted Analysis 5%
• International Agency for Research on Cancer 5%
• Nuclear Magnetic Resonance 5%
• Laboratory Animals 5%
• Pyridyl 5%
• Hydroxylation 5%
• Glucuronide 5%
• Butanoic Acid 5%
• Methylthiol 5%
• Major Metabolites 5%
• Isotopic Labeling 5%
• F344 Rats 5%
• Pyridine 5%
• Tobacco Users 5%
• N-acetylation 5%
• Pyrrol 5%
• Carcinogenicity 5%
• Human Urine 5%
• Pyrrole 5%
• New Biomarkers 5%
• Synthetic Standards 5%
• N-oxides 5%
• Human Groups 5%
• 2-Butanone 5%
• Isotopically Labelled Standards 5%

Chemistry

• Mass Spectrometry 100%
• Metabolic 100%
• Metabolite 100%
• Biological Marker 37%
• Metabolic Activation 37%
• High Resolution Mass Spectrometry (HRMS) 25%
• NMR Spectroscopy 12%
• Acetyl 12%
• Pyrrole 12%
• Hydroxylation 12%
• Butanone 12%
• Nitrosamine 12%
• Carcinogenic 12%
• N-Oxide 12%
• Isotope Labelling Method 12%
• Cysteine 12%
• Butyric Acid 12%

Pharmacology, Toxicology and Pharmaceutical Science

• N-Nitrosonornicotine 100%
• Biological Marker 15%
• Experimental Animal 5%
• Tobacco-Specific Nitrosamines 5%
• NNK 5%
• Glucuronide 5%
• Butyrate 5%
• Fischer 344 Rat 5%
• Malignant Neoplasm 5%
• Pyrrole 5%
• Cysteine 5%
• 2 Butanone 5%
• Carcinogenicity 5%
• Acetic Acid Derivative 5%