Mass spectrometry-based assay for the rapid detection of thiol-containing natural products

Stacy L. Capehart, Erin E. Carlson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Natural products are privileged scaffolds due to their high propensity to possess bioactivity. To expedite discovery of thiol-containing compounds, we devised a selective solid-supported reagent for their immobilization, followed by cleavage of a photocleavable linker to yield stable natural product conjugates for direct detection by mass spectrometry. Importantly, the natural products can also be tracelessly released to yield the native structures for chemical and biological evaluation.

Original languageEnglish (US)
Pages (from-to)13229-13232
Number of pages4
JournalChemical Communications
Volume52
Issue number90
DOIs
StatePublished - Jan 1 2016

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