Mass Spectrometric Characterization of an Acid-Labile Adduct Formed with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Albumin in Humans

Keyphrases

• Mass Spectrometry 100%
• PhIP 100%
• Albumin 100%
• Acid-labile 100%
• 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine 100%
• Spectrometric Characterization 100%
• Acid Treatment 30%
• Sulfinamides 30%
• Cys34 30%
• 1-Methyl 20%
• Pyridine 20%
• Heterocyclic Aromatic Amines 10%
• Cytochrome P450 (CYP450) 10%
• Meat 10%
• Covalently Bound 10%
• Buffer pH 10%
• Electrophilic 10%
• Epidemiol 10%
• 14C-labelled 10%
• Hydrolysis Products 10%
• Human Volunteers 10%
• Amine Group 10%
• Pronase 10%
• Bicarbonate Buffer 10%
• High Performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS) 10%
• Mass Spectrometry Methods 10%
• N-linked 10%
• 1 M HCl 10%
• Proteolytic Digestion 10%
• 2-amino-1 10%
• Human Albumin 10%
• Accelerator Mass Spectrometry 10%
• Orbitrap MS 10%
• Pressure Cooking 10%
• N-hydroxylation 10%
• Ammonium Bicarbonate 10%
• Acid Protease 10%
• Exocyclic Amines 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Carbon 14 100%
• Sulfinamide 66%
• Malignant Neoplasm 33%
• Biological Marker 33%
• Proteinase 33%
• Cytochrome P450 33%
• Buffer 33%
• Pronase 33%
• Human Albumin 33%
• Sulfenamide 33%
• Aromatic Amine 33%