Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns

Paul S. Stadem, Megan V. Hilgers, Derrick Bengo, Sarah E. Cusick, Susan Ndidde, Tina M. Slusher, Troy C. Lund

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder that affects as many as 400 million people worldwide, making it the most common enzymatic defect. Subjects with G6PD deficiency are more likely to develop neonatal hyperbilirubinemia potentially leading to kernicterus and are at increased risk for acute hemolytic anemia when exposed to pro-oxidant compounds such as anti-malarial drugs. We collected umbilical cord blood from 300 males born in Uganda to assess for novel markers of systemic oxidative stress. We determined that 10.7% of the samples collected were G6PD A- deficient (G202A/A376G) and when these were compared with unaffected controls, there was significantly higher 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentration, elevated ferritin, increased leukocyte count and higher small molecule antioxidant capacity. These data suggest increased baseline oxidative stress and an elevated antioxidant response in umbilical cord blood of patients with G6PD deficiency.

Original languageEnglish (US)
Article numbere0172980
JournalPloS one
Issue number2
StatePublished - Feb 2017

Bibliographical note

Publisher Copyright:
© 2017 Stadem et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Fingerprint Dive into the research topics of 'Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns'. Together they form a unique fingerprint.

Cite this