Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns

Paul S. Stadem, Megan V. Hilgers, Derrick Bengo, Sarah E. Cusick, Susan Ndidde, Tina M. Slusher, Troy C. Lund

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder that affects as many as 400 million people worldwide, making it the most common enzymatic defect. Subjects with G6PD deficiency are more likely to develop neonatal hyperbilirubinemia potentially leading to kernicterus and are at increased risk for acute hemolytic anemia when exposed to pro-oxidant compounds such as anti-malarial drugs. We collected umbilical cord blood from 300 males born in Uganda to assess for novel markers of systemic oxidative stress. We determined that 10.7% of the samples collected were G6PD A- deficient (G202A/A376G) and when these were compared with unaffected controls, there was significantly higher 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentration, elevated ferritin, increased leukocyte count and higher small molecule antioxidant capacity. These data suggest increased baseline oxidative stress and an elevated antioxidant response in umbilical cord blood of patients with G6PD deficiency.

Original languageEnglish (US)
Article numbere0172980
JournalPloS one
Volume12
Issue number2
DOIs
StatePublished - Feb 2017

Fingerprint

Glucosephosphate Dehydrogenase Deficiency
umbilical cord
Oxidative stress
Glucosephosphate Dehydrogenase
glucose-6-phosphate 1-dehydrogenase
Fetal Blood
Blood Glucose
neonates
Oxidative Stress
oxidative stress
Newborn Infant
blood
Blood
Antioxidants
Neonatal Hyperbilirubinemia
Kernicterus
Uganda
Hemolytic Anemia
Antimalarials
Ferritins

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Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns. / Stadem, Paul S.; Hilgers, Megan V.; Bengo, Derrick; Cusick, Sarah E.; Ndidde, Susan; Slusher, Tina M.; Lund, Troy C.

In: PloS one, Vol. 12, No. 2, e0172980, 02.2017.

Research output: Contribution to journalArticle

Stadem, Paul S. ; Hilgers, Megan V. ; Bengo, Derrick ; Cusick, Sarah E. ; Ndidde, Susan ; Slusher, Tina M. ; Lund, Troy C. / Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns. In: PloS one. 2017 ; Vol. 12, No. 2.
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