Marked hypodiploidy in blast phase chronic myelogenous leukemia: Report of a case and review of the literature

Michael L. Cibull, Mark E. Thompson, Linda Smith, C. Darrell Jennings, Michael A. Doukas, Edward J. Pavlik, Deborah E. Powell

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The emergence of a near‐haploid clone of cells in blast phase chronic myelogenous leukemia is an unusual event. We report such a case and review eight other cases described in the English literature. The significance of the substantial loss of genetic material is discussed as is the phenotypic and genotypic heterogeneity observed in this group of patients.

Original languageEnglish (US)
Pages (from-to)293-299
Number of pages7
JournalAmerican Journal of Hematology
Volume24
Issue number3
DOIs
StatePublished - Mar 1987

Keywords

  • blast phase chronic myelogenous leukemia
  • cytogenetics
  • hypodiploidy

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