Mapping of the gene encoding the β-subunit of H+,K+-ATPase to human chromosome 13q34 by fluorescence in situ hybridization

Il Song, David R. Brown, Tadataka Yamada, Jeffrey M. Trent

Research output: Contribution to journalArticlepeer-review

13 Scopus citations
Original languageEnglish (US)
Pages (from-to)1114-1115
Number of pages2
Issue number4
StatePublished - Dec 1992

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The genes encoding the a-and /3-subunits of gastric H+,K+-ATPase from several mammalian species have been cloned and sequenced. In contrast to the 22-exon gene encoding the a-subunit (7, 10), the/3-subunit is encoded on a gene comprising 7 exons (1, 7, 11). The human H+,K+-ATPase /3-subunit is encoded on a 1.4-kb-long cDNA (5). Its deduced amino acid sequence bears >80% identity to that of rabbits, rodents, cattle, and swine (13, 14, 16). Using fluorescence in situ hybridization (FISH), we have recently mapped the gene 1 This work was supported in part by NIH Grants R01-DK34306, R01-DK33500, and P30-CA-46592 and funds from the University of Michigan Gastrointestinal Peptide Research Center (NIH Grant P30-DK34933). D.R.B. is a Visiting Research Investigator supported in part by National Research Service Award F33-DK08686.

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