Abstract
To map the site involved in Mannheimia haemolytica leukotoxin (LktA) binding and biological activity within bovine CD18, bovine × human CD18 chimeric constructs were generated and coexpressed with bovine CD11a in K562 cells. Studies with the chimeric leukocyte function-associated antigen 1 transductants demonstrate that the site required for LktA binding and biological effects resides within amino acid residues 500 and 600 of the extracellular region of bovine CD18.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5233-5237 |
| Number of pages | 5 |
| Journal | Infection and immunity |
| Volume | 73 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2005 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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