Tonotopic mapping in auditory cortex of the adult chinchilla with amikacin-induced cochlear lesions

Akinobu Kakigi, Haruo Hirakawa, Noam Harel, Richard J. Mount, Robert V. Harrison

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


We have found a reorganization of tonotopic maps (based on neuron response thresholds) in primary auditory cortex of the adult chinchilla after amikacin-induced basal cochlear lesions. We find an over-representation of a frequency that corresponds to the border area of the cochlear lesion. The reorganization observed is similar in extent to that previously seen in a developmental model. The properties of neurons within the over-represented area were investigated in order to determine whether their responses originated from a common input (an indication of true plasticity) or represented only the result of truncating the activity of the sensory epithelium (“pseudo-plasticity”). Some aspects of our data fit with a true plasticity model and indicate the potential for the deafferented cortex of the mature cortex to regain connections with the surviving sensory epithelium.

Original languageEnglish (US)
Pages (from-to)153-160
Number of pages8
JournalInternational Journal of Phytoremediation
Issue number3
StatePublished - 2000


  • Amikacin
  • Aminoglycoside
  • Auditory brainstem response audiogram
  • Auditory cortex
  • Cochleogram
  • Cortical mapping
  • Ototoxicity
  • Plasticity
  • Scanning electron microscopy
  • Single-unit electrophysiology


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