TY - JOUR
T1 - Manipulation of pH-Sensitive interactions between podophyllotoxin-chitosan for enhanced controlled drug release
AU - Chen, Chao
AU - Yu, Yong
AU - Wang, Xiaoli
AU - Shi, Ping
AU - Wang, Yibing
AU - Wang, Ping
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Podophyllotoxin (PPT) offers a broad-spectrum of anticancer activities, but little has been reported for its controlled release. This work shows that by manipulating molecular interactions between PPT and Chitosan, efficient nanoscale capsulation of PPT can be realized. The drug encapsulation efficiency is as high as 52%, with a final particle drug loading in the order of 10% (wt/wt). It further demonstrates that changes in pH can also significantly affect the rate of drug release from the Chitosan nanoparticles. Upon contact with cancer cells, chitosan nanoparticles enable efficient internalization and drug release. In vitro evaluations with HepG-2 and MCF-7 cells indicate that the chitosan nanoparticle carriers can improve drug efficacy in comparison to free PPT, most likely by regulating the intrinsic apoptotic signaling pathway to induce apoptosis. Overall, PPT chitosan nanoparticles promise a safe and efficient drug delivery system for PPT.
AB - Podophyllotoxin (PPT) offers a broad-spectrum of anticancer activities, but little has been reported for its controlled release. This work shows that by manipulating molecular interactions between PPT and Chitosan, efficient nanoscale capsulation of PPT can be realized. The drug encapsulation efficiency is as high as 52%, with a final particle drug loading in the order of 10% (wt/wt). It further demonstrates that changes in pH can also significantly affect the rate of drug release from the Chitosan nanoparticles. Upon contact with cancer cells, chitosan nanoparticles enable efficient internalization and drug release. In vitro evaluations with HepG-2 and MCF-7 cells indicate that the chitosan nanoparticle carriers can improve drug efficacy in comparison to free PPT, most likely by regulating the intrinsic apoptotic signaling pathway to induce apoptosis. Overall, PPT chitosan nanoparticles promise a safe and efficient drug delivery system for PPT.
KW - Cancer treatment
KW - Chitosan nanoparticles
KW - Controlled release
KW - Podophyllotoxin
KW - pH-sensitivity
UR - http://www.scopus.com/inward/record.url?scp=84999054233&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84999054233&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2016.11.053
DO - 10.1016/j.ijbiomac.2016.11.053
M3 - Article
C2 - 27867056
AN - SCOPUS:84999054233
VL - 95
SP - 451
EP - 461
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
SN - 0141-8130
ER -