Management of type IV hyperlipoproteinemia: evaluation of practical clinical approaches

L. K. Smith, R. V. Luepker, S. S. Rothchild, A. Gillis, L. Kochman, J. R. Warbasse

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A lipid intervention clinic screened 4000 employees (89% participation) and identified 150 type IV subjects (top 5 percentile triglyceride values, 100% initial participation, 6% drop out). The 150 healthy type IV subjects, ages 20 to 49, were randomly divided into treatment subgroups: A, treatment by clinic nutritionist and physician with the National Heart and Lung Institute's type IV diet for 6 weeks, then diet plus clofibrate for 18 weeks; B, same treatment by private physician; C, no intervention for 24 weeks, subjects advised of abnormality. The group A mean fasting serum triglyceride of 407 mg/dl declined 50% at 6 weeks, 61% at 12 weeks, and was unchanged at 24 weeks (p<0.0005 at 6, 12, 24 weeks). Group B triglyceride decreased 42%, 50%, 41% (p<0.0005) at 6, 12, 24 weeks). Group C triglyceride declined 20%, 1st to 24th week. Body weight decreased 8% (A) and 4% (B) at 6 weeks (p<0.0005) and was unchanged at 24 weeks. The maximum cholesterol decrease (A) was 11% (p<0.0005). Type IV hyperlipoproteinemia can readily be identified in a working population; treatment by clinic or private physician will markedly lower fasting serum triglyceride values in apparently healthy type IV subjects for at least 24 weeks.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
JournalUnknown Journal
Issue number1
StatePublished - Jan 1 1976


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