Abstract
The therapeutic efficacy of four antihypertensive regimens (minoxidil, propranolol, andhydrochlorothiazide; propranolol and hydrochlorothiazide; methyldopa and hydrochlorothiazide; and hydrochlorothiazide alone) was evaluated in one child with systolic hypertension and in eight children with systolic and diastolic hypertension. The mean blood pressure of 148/98±8/4 mm Hg observed during the hydrochlorothiazide control period fell to 142/88±8/4 mm Hg following methyldopa and hydrochlorothiazide, 141/85±6/2 mm Hg following propranolol and hydrochlorothiazide, and 128/74±4/2 mm Hg following minoxidil, propranolol, and hydrochlorothiazide. The only side effect directly associated with administration of minoxidil was hypertrichosis. The effectiveness of minoxidil in the present study suggests that this drug offers an important adjunct to current antihypertensive therapy in children.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 138-142 |
| Number of pages | 5 |
| Journal | The Journal of pediatrics |
| Volume | 91 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1977 |
Bibliographical note
Funding Information:From the Division of Clinical Pharmacology, Departments of Pediatrics and Pharmacology, University of Minnesota Medical School. Supported in part by a grant in Developmental and Clinical Pediatric Pharmacology from the National Institute of ChiM Health and Development (HD 08580) and the Upjohn Pharmaceutical Company. *Reprint address: Division of Clinical Pharmacology, Departments of Pediatrics and Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455.