Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?

Stuart E. Samuels; Avraham Eisbruch; Jonathan J. Beitler; June Corry; Carol R. Bradford; Nabil F. Saba; Michiel W.M. van den Brekel; Robert Smee; Primož Strojan; Carlos Suárez; William M. Mendenhall; Robert P. Takes; Juan P. Rodrigo; Missak Haigentz; Alexander D. Rapidis; Alessandra Rinaldo; Alfio Ferlito

doi:10.1007/s00405-015-3771-x

Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?

Stuart E. Samuels
, Avraham Eisbruch
, Jonathan J. Beitler
, June Corry
, Carol R. Bradford
, Nabil F. Saba
, Michiel W.M. van den Brekel
, Robert Smee
, Primož Strojan
, Carlos Suárez
, William M. Mendenhall
, Robert P. Takes
, Juan P. Rodrigo
, Missak Haigentz
, Alexander D. Rapidis
, Alessandra Rinaldo
, Alfio Ferlito

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.

Original language	English (US)
Pages (from-to)	2877-2894
Number of pages	18
Journal	European Archives of Oto-Rhino-Laryngology
Volume	273
Issue number	10
DOIs	https://doi.org/10.1007/s00405-015-3771-x
State	Published - Oct 1 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cetuximab
EGFR
HPV
Hypoxia
Oropharyngeal carcinoma
p16
Radiosensitivity
TORS
Treatment de-intensification

Publisher link

10.1007/s00405-015-3771-x

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Samuels, S. E., Eisbruch, A., Beitler, J. J., Corry, J., Bradford, C. R., Saba, N. F., van den Brekel, M. W. M., Smee, R., Strojan, P., Suárez, C., Mendenhall, W. M., Takes, R. P., Rodrigo, J. P., Haigentz, M., Rapidis, A. D., Rinaldo, A., & Ferlito, A. (2016). Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we? European Archives of Oto-Rhino-Laryngology, 273(10), 2877-2894. https://doi.org/10.1007/s00405-015-3771-x

Samuels, SE, Eisbruch, A, Beitler, JJ, Corry, J, Bradford, CR, Saba, NF, van den Brekel, MWM, Smee, R, Strojan, P, Suárez, C, Mendenhall, WM, Takes, RP, Rodrigo, JP, Haigentz, M, Rapidis, AD, Rinaldo, A & Ferlito, A 2016, 'Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?', European Archives of Oto-Rhino-Laryngology, vol. 273, no. 10, pp. 2877-2894. https://doi.org/10.1007/s00405-015-3771-x

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abstract = "HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.",

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doi = "10.1007/s00405-015-3771-x",

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AU - van den Brekel, Michiel W.M.

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AU - Strojan, Primož

AU - Suárez, Carlos

AU - Mendenhall, William M.

AU - Takes, Robert P.

AU - Rodrigo, Juan P.

AU - Haigentz, Missak

AU - Rapidis, Alexander D.

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

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AB - HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.

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KW - Hypoxia

KW - Oropharyngeal carcinoma

KW - p16

KW - Radiosensitivity

KW - TORS

KW - Treatment de-intensification

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ER -

Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?

Abstract

Bibliographical note

UN SDGs

Keywords

Publisher link

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