Management of hypercholesterolemia: Evaluation of practical clinical approaches in healthy young adults

Russell V. Luepker, L. Kent Smith, Sarah S. Rothchild, Albert Gillis, Leon Kochman, J. Richard Warbasse

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A work site-located clinic screened 6,000 employees (91 percent participation) and identified 146 hypercholesterolemic subjects (100 percent initial participation, 12 percent subsequent dropout rate). The subjects, aged 20 to 50 years, were randomly classified into four groups: Group A, treatment in a lipid intervention clinic with diet for 6 weeks, then diet plus clofibrate for the subsequent 18 weeks; Group B, diet treatment from a clinic nutritionist with the cooperation of the subject's private physician; Group C, referral for treatment by a private physician; and Group D, no intervention. Initial mean cholesterol was 294 mg/100 ml. At 24 weeks, all intervention groups had decreases in serum cholesterol (Group A, 12 percent; Group B, 15 percent; Group C, 17 percent; P < 0.001). The control group (D) had a small decrease in cholesterol (4 percent). Decreases in cholesterol were correlated with weight loss and decrease in fasting serum triglycerides but not with the use of clofibrate. Serum cholesterol can be reduced in healthy young adults by several practical methods.

Original languageEnglish (US)
Pages (from-to)590-596
Number of pages7
JournalThe American journal of cardiology
Volume41
Issue number3
DOIs
StatePublished - Mar 1978

Fingerprint Dive into the research topics of 'Management of hypercholesterolemia: Evaluation of practical clinical approaches in healthy young adults'. Together they form a unique fingerprint.

Cite this