Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer

Keyphrases

• Transgenic Mouse Model 100%
• Tumor Metastasis 100%
• Tumor Formation 100%
• Human Breast Cancer 100%
• Mammary Epithelial 100%
• Focal Adhesion Kinase 100%
• Tumor Progression 30%
• Clinically Significant 20%
• Tumor Initiation 20%
• Metastasis-related Genes 20%
• Gene Signature 20%
• Computational Analysis 10%
• Novel Therapeutics 10%
• Transcription Factor 10%
• Cell Proliferation 10%
• Signaling Network 10%
• Overexpression 10%
• Human Cancer 10%
• Ontology 10%
• Cell Survival 10%
• System-level Analysis 10%
• Cell Migration 10%
• Therapeutic Intervention 10%
• Tumor-specific Transcripts 10%
• Signaling Complex 10%
• Differentially Expressed 10%
• Growth Factor Signaling Pathways 10%
• Null Cell 10%
• Mammary Epithelium 10%
• Focal Adhesion 10%
• Cre-Lox Technology 10%
• Gene Set 10%
• Transcription Factor Binding Sites 10%
• M Phase 10%
• Relevant Genes 10%
• Multiple Signalling 10%
• Central Regulator 10%
• Motile Cells 10%
• P130Cas 10%
• Adhesion Factor 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Transgenic Mouse 100%
• Mouse Model 100%
• Breast Cancer 100%
• Focal Adhesion Kinase 100%
• Carcinogenesis 100%
• Janus Kinase 1 100%
• Neoplasm 30%
• Tumor Growth 20%
• Transcription Factors 20%
• Growth Factor 10%
• Malignant Neoplasm 10%
• Binding Site 10%
• Protein P53 10%
• Transcriptome 10%

Biochemistry, Genetics and Molecular Biology

• Mouse Model 100%
• Transgenic Mouse 100%
• Carcinogenesis 100%
• Janus Kinase 1 100%
• Tumor Progression 30%
• Gene Signature 20%
• Tumor Initiation 20%
• Transcription Factors 20%
• Cell Migration 10%
• Cell Survival 10%
• Cell Cycle 10%
• Binding Site 10%
• Cell Proliferation 10%
• Focal Adhesion 10%
• Cell Cycle M Phase 10%
• LoxP Site 10%
• P53 10%
• Transcriptome 10%
• Growth Factor Signaling 10%