Malignancy-associated multicentric reticulohistiocytosis

Boutros El-Haddad; Dalia Hammoud; Timothy Shaver; Shadi Shahouri

doi:10.1007/s00296-009-1287-7

Malignancy-associated multicentric reticulohistiocytosis

Boutros El-Haddad, Dalia Hammoud, Timothy Shaver, Shadi Shahouri

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Multicentric reticulohistiocytosis (MR) is a rare systemic disorder of unknown etiology. Up to 25% of patients with MR have associated malignancies. We are reporting a case of a patient with MR who initially had an excellent clinical response to oral methotrexate and prednisone. Subsequent attempts of prednisone taper failed because of disease flare-up. Workup for associated malignancy revealed localized squamous cell carcinoma of the lung. The tumor was resected; methotrexate and prednisone were tapered and discontinued with complete remission of MR. A review of literature and the new advances and treatment modalities for MR is provided.

Original language	English (US)
Pages (from-to)	1235-1238
Number of pages	4
Journal	Rheumatology International
Volume	31
Issue number	9
DOIs	https://doi.org/10.1007/s00296-009-1287-7
State	Published - Sep 2011
Externally published	Yes

Keywords

Histiocytes
Malignancy
Multicentric reticulohistiocytosis
Multinucleated giant cells
Paraneoplastic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00296-009-1287-7

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title = "Malignancy-associated multicentric reticulohistiocytosis",

abstract = "Multicentric reticulohistiocytosis (MR) is a rare systemic disorder of unknown etiology. Up to 25% of patients with MR have associated malignancies. We are reporting a case of a patient with MR who initially had an excellent clinical response to oral methotrexate and prednisone. Subsequent attempts of prednisone taper failed because of disease flare-up. Workup for associated malignancy revealed localized squamous cell carcinoma of the lung. The tumor was resected; methotrexate and prednisone were tapered and discontinued with complete remission of MR. A review of literature and the new advances and treatment modalities for MR is provided.",

keywords = "Histiocytes, Malignancy, Multicentric reticulohistiocytosis, Multinucleated giant cells, Paraneoplastic",

author = "Boutros El-Haddad and Dalia Hammoud and Timothy Shaver and Shadi Shahouri",

year = "2011",

month = sep,

doi = "10.1007/s00296-009-1287-7",

language = "English (US)",

volume = "31",

pages = "1235--1238",

journal = "Rheumatology International",

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TY - JOUR

T1 - Malignancy-associated multicentric reticulohistiocytosis

AU - El-Haddad, Boutros

AU - Hammoud, Dalia

AU - Shaver, Timothy

AU - Shahouri, Shadi

PY - 2011/9

Y1 - 2011/9

N2 - Multicentric reticulohistiocytosis (MR) is a rare systemic disorder of unknown etiology. Up to 25% of patients with MR have associated malignancies. We are reporting a case of a patient with MR who initially had an excellent clinical response to oral methotrexate and prednisone. Subsequent attempts of prednisone taper failed because of disease flare-up. Workup for associated malignancy revealed localized squamous cell carcinoma of the lung. The tumor was resected; methotrexate and prednisone were tapered and discontinued with complete remission of MR. A review of literature and the new advances and treatment modalities for MR is provided.

AB - Multicentric reticulohistiocytosis (MR) is a rare systemic disorder of unknown etiology. Up to 25% of patients with MR have associated malignancies. We are reporting a case of a patient with MR who initially had an excellent clinical response to oral methotrexate and prednisone. Subsequent attempts of prednisone taper failed because of disease flare-up. Workup for associated malignancy revealed localized squamous cell carcinoma of the lung. The tumor was resected; methotrexate and prednisone were tapered and discontinued with complete remission of MR. A review of literature and the new advances and treatment modalities for MR is provided.

KW - Histiocytes

KW - Malignancy

KW - Multicentric reticulohistiocytosis

KW - Multinucleated giant cells

KW - Paraneoplastic

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U2 - 10.1007/s00296-009-1287-7

DO - 10.1007/s00296-009-1287-7

M3 - Review article

C2 - 20012625

AN - SCOPUS:80054936737

SN - 0172-8172

VL - 31

SP - 1235

EP - 1238

JO - Rheumatology International

JF - Rheumatology International

IS - 9

ER -

Malignancy-associated multicentric reticulohistiocytosis

Abstract

Keywords

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