Malignancy-associated multicentric reticulohistiocytosis

Boutros El-Haddad, Dalia Hammoud, Timothy Shaver, Shadi Shahouri

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Multicentric reticulohistiocytosis (MR) is a rare systemic disorder of unknown etiology. Up to 25% of patients with MR have associated malignancies. We are reporting a case of a patient with MR who initially had an excellent clinical response to oral methotrexate and prednisone. Subsequent attempts of prednisone taper failed because of disease flare-up. Workup for associated malignancy revealed localized squamous cell carcinoma of the lung. The tumor was resected; methotrexate and prednisone were tapered and discontinued with complete remission of MR. A review of literature and the new advances and treatment modalities for MR is provided.

Original languageEnglish (US)
Pages (from-to)1235-1238
Number of pages4
JournalRheumatology International
Issue number9
StatePublished - Sep 2011
Externally publishedYes


  • Histiocytes
  • Malignancy
  • Multicentric reticulohistiocytosis
  • Multinucleated giant cells
  • Paraneoplastic


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