Making a Murderer

The Evolutionary Framing of Hybrid Gamete-Killers

Andrea L. Sweigart, Yaniv J Brandvain, Lila Fishman

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Recent molecular investigations of hybrid incompatibilities have revealed fascinating patterns of genetic interactions that have been interpreted as the remnants of a history of selfish evolution. Instead of framing hybrid incompatibilities in light of genetic conflict, we advocate assuming their innocence. Researchers must build a strong theory for each case, supported by population genetic evidence, such that the role of conflict in the evolution of a hybrid incompatibility can be proven beyond reasonable doubt. This will require careful investigation of the evolutionary history of these incompatibilities, a reckoning of how the reproductive biology of study organisms impacts on the likelihood of genetic conflict, and molecular evidence of the rapid selfish spread of these alleles.

Original languageEnglish (US)
Pages (from-to)245-252
Number of pages8
JournalTrends in Genetics
Volume35
Issue number4
DOIs
StatePublished - Apr 1 2019

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Germ Cells
Population Genetics
Molecular Biology
History
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Research Personnel

Keywords

  • epistasis
  • gamete-killers
  • hybrid incompatibilities
  • selfish evolution

PubMed: MeSH publication types

  • Journal Article
  • Review

Cite this

Making a Murderer : The Evolutionary Framing of Hybrid Gamete-Killers. / Sweigart, Andrea L.; Brandvain, Yaniv J; Fishman, Lila.

In: Trends in Genetics, Vol. 35, No. 4, 01.04.2019, p. 245-252.

Research output: Contribution to journalReview article

Sweigart, Andrea L. ; Brandvain, Yaniv J ; Fishman, Lila. / Making a Murderer : The Evolutionary Framing of Hybrid Gamete-Killers. In: Trends in Genetics. 2019 ; Vol. 35, No. 4. pp. 245-252.
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