Major routes of metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the rat

R. J. Turesky, H. U. Aeschbacher, H. P. Würzner, P. L. Skipper, S. R. Tannenbaum

Research output: Contribution to journalComment/debate

Abstract

A metabolite of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was incorrectly characterized in this paper. The metabolite was thought to be an acetyl conjugate of the 5-hydroxyl-ated derivative of MeIQx. This assignment is incorrect. The correct assignment is a sulfate conjugate of 5-hydroxy-MeIQx, 2-amino-3,8-dimethylirnidazo[4,5-f]quinoxaUn-5-yl-sulfate. This conclusion is based upon repurified sample analyzed by 1H NMR and 13C NMR, enzyme hydrolysis assays, IR spectro-scopy and FAB/MS (accurate mass measurement).

Original languageEnglish (US)
Number of pages1
JournalCarcinogenesis
Volume10
Issue number9
DOIs
StatePublished - Sep 1 1989

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