Major hemorrhage from endoscopic sphincterotomy: risk factor analysis

Douglas B. Nelson, Martin L. Freeman

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

We carried out a retrospective cohort study on all patients undergoing sphincterotomy at our institution over a 4-year period. Major hemorrhage occurred in 10 of 189 patients (5.3%). Onset was usually delayed (mean, 3.0 days; range, 0-9 days). Six potential risk factors for postsphincterotomy hemorrhage were assessed by univariate and multivariate analysis. Three factors predicted postsphincterotomy hemorrhage: hemodialysis (relative risk, 8.4; 95% confidence interval, CI, 2.7-26.4), a prothrombin time prolonged at least 2 s above control (relative risk, 7.8; 95% CI, 2.4-25.6), and endoscopically observed bleeding at the time of sphincterotomy (relative risk, 5.9; 95% CI, 1.7-20.1). Features not independently associated with hemorrhage were sphincter of Oddi dysfunction, aspirin or nonsteroidal anti-inflammatory drug (NSAID) use within 1 week prior to sphincterotomy, and sphincterotomy length. When differentiated from endoscopically observed bleeding, clinically significant hemorrhage was usually a delayed complication, primarily in patients with hemostatic defects.

Original languageEnglish (US)
Pages (from-to)283-287
Number of pages5
JournalJournal of clinical gastroenterology
Volume19
Issue number4
DOIs
StatePublished - Dec 1994

Keywords

  • Aspirin
  • Endoscopic retrograde cholangiopancreatography
  • Hemorrhage
  • Nonsteroidal anti-inflammatory drugs
  • Sphincterotomy

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