Abstract
A general approach to the selection of the maintenance dose (Dm) required to give a desired steady‐state concentration of drug based on a single determination of concentration after a test dose (C*) is extended to drugs with two‐compartment pharmacokinetic characteristics. Using the equation developed, the value of the proportionality factor relating 1/Dm to C* was found to be within 3.2% of the value calculated from a published nomogram for lithium. The inherent error is shown to be a function of the value of the hybrid rate constants α and β, as well as the value of an intercompartmental transfer rate constant, k21, in an individual.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1262-1266 |
| Number of pages | 5 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 72 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1983 |
| Externally published | Yes |
Bibliographical note
Funding Information:The authors thank Dr. E. M. Hawes for helpful discussions and Mr. K. Hall for mass spectral analysis. The postdoctoral award from Sas- katchewan Health Research Board to G. McKay is gratefully acknowledged.
Keywords
- Concentration, steady‐state—maintenance dose, prediction by single determination of concentration, two‐compartment pharmacokinetics, lithium
- Dose, maintenance—steady‐state concentration, prediction by single determination of concentration, two‐compartment pharmacokinetics, lithium
- Pharmacokinetics—two‐compartment, maintenance dose for steady‐state concentration, prediction by single determination of concentration, lithium
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