Maintenance‐dose prediction based on a single determination of concentration: General applicability to two‐compartment drugs with reference to lithium

Cheryl L. Zimmerman, John T. Slattery

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A general approach to the selection of the maintenance dose (Dm) required to give a desired steady‐state concentration of drug based on a single determination of concentration after a test dose (C*) is extended to drugs with two‐compartment pharmacokinetic characteristics. Using the equation developed, the value of the proportionality factor relating 1/Dm to C* was found to be within 3.2% of the value calculated from a published nomogram for lithium. The inherent error is shown to be a function of the value of the hybrid rate constants α and β, as well as the value of an intercompartmental transfer rate constant, k21, in an individual.

Original languageEnglish (US)
Pages (from-to)1262-1266
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume72
Issue number11
DOIs
StatePublished - Nov 1983
Externally publishedYes

Bibliographical note

Funding Information:
The authors thank Dr. E. M. Hawes for helpful discussions and Mr. K. Hall for mass spectral analysis. The postdoctoral award from Sas- katchewan Health Research Board to G. McKay is gratefully acknowledged.

Keywords

  • Concentration, steady‐state—maintenance dose, prediction by single determination of concentration, two‐compartment pharmacokinetics, lithium
  • Dose, maintenance—steady‐state concentration, prediction by single determination of concentration, two‐compartment pharmacokinetics, lithium
  • Pharmacokinetics—two‐compartment, maintenance dose for steady‐state concentration, prediction by single determination of concentration, lithium

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