Maintenance ketamine treatment produces long-term recovery from depression

Michael M. Messer, Irina V. Haller

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Patients not responding to conventional treatment for depression are classified as having treatment-resistant depression (TRD). Electroconvulsive therapy is effective in ~50% of the patients diagnosed with TRD. Recent reports of rapid antidepressant effect with a single dose of ketamine suggest a potential benefit for TRD patients. However, there are no studies characterizing optimal dosing parameters (eg, frequency and inter-dose interval). The following case describes the effects of two ketamine administration regimens in a patient with a 15-year history of depression.

Original languageEnglish (US)
Pages (from-to)48-50
Number of pages3
JournalPrimary Psychiatry
Issue number4
StatePublished - Apr 1 2010


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