Maintaining the norm: T-cell homeostasis

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483 Scopus citations

Abstract

The persistence of naive and memory T cells has long been of interest to immunologists, but the factors that influence the survival and homeostasis of these subsets have remained obscure. In recent years, it has become evident that the homeostasis of both naive and memory T-cell pools is highly dynamic and tightly regulated by internal stimuli, including cytokines and self-peptide-MHC ligands for the T-cell receptor. These homeostatic mechanisms might have a vital influence on the capacity of the T-cell pool to respond to both foreign and self-antigens.

Original languageEnglish (US)
Pages (from-to)547-556
Number of pages10
JournalNature Reviews Immunology
Volume2
Issue number8
DOIs
StatePublished - Aug 2002

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