Abstract
The synthesis and properties of two luminescent iron oxide nanoparticles for dual imaging by MRI and time-gated confocal microscopy are presented. These magnetoplasmonic agents consist of macrocyclic terbium complexes conjugated onto magnetite nanoparticles by a polyethylene glycol linker. Two macrocyclic terbium complexes were investigated: Tb-DOTAm-(Phen) 3 and Tb-DOTAm-(acetylene) 3. Both complexes display the characteristic long luminescence lifetimes of lanthanides (0.8 ms and 1.3 ms, respectively), rendering them ideal for time-gated luminescence spectroscopy and confocal imaging - a feature currently unexplored in multimodal imaging agents. Additionally, the 5 ± 1 nm magnetite nanoparticles, with their permeable PEG coating and stable dopamide anchor, render the two constructs efficient MRI contrast agents with longitudinal (r 1) and transverse (r 2) relaxivities of 9.8 mM -1 Fe s -1 and 98 mM -1 Fe s -1 at 60 MHz and 37 °C. The synthesis and characterization of Fe 3O 4@Tb-DOTAm-(acetylene) 3 and Fe 3O 4@Tb-DOTAm-(Phen) 3, two magnetoluminescent agents for dual imaging by MRI and confocal imaging are presented. The nanoparticles are characterized by high transverse and longitudinal relaxivities and long luminescence lifetimes ideal for time-gated spectroscopy.
Original language | English (US) |
---|---|
Pages (from-to) | 2141-2147 |
Number of pages | 7 |
Journal | European Journal of Inorganic Chemistry |
Issue number | 12 |
DOIs | |
State | Published - Apr 2012 |
Keywords
- Lanthanides
- Luminescence
- MRI
- Nanoparticles
- Time-gated spectroscopy