Magnetoluminescent agents for dual MRI and time-gated fluorescence imaging

Eric D. Smolensky, Yue Zhou, Valérie C. Pierre

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The synthesis and properties of two luminescent iron oxide nanoparticles for dual imaging by MRI and time-gated confocal microscopy are presented. These magnetoplasmonic agents consist of macrocyclic terbium complexes conjugated onto magnetite nanoparticles by a polyethylene glycol linker. Two macrocyclic terbium complexes were investigated: Tb-DOTAm-(Phen)3 and Tb-DOTAm-(acetylene)3. Both complexes display the characteristic long luminescence lifetimes of lanthanides (0.8 ms and 1.3 ms, respectively), rendering them ideal for time-gated luminescence spectroscopy and confocal imaging - a feature currently unexplored in multimodal imaging agents. Additionally, the 5 ± 1 nm magnetite nanoparticles, with their permeable PEG coating and stable dopamide anchor, render the two constructs efficient MRI contrast agents with longitudinal (r1) and transverse (r2) relaxivities of 9.8 mM-1Fe s-1 and 98 mM -1Fe s-1 at 60 MHz and 37 °C. The synthesis and characterization of Fe3O4@Tb-DOTAm-(acetylene) 3 and Fe3O4@Tb-DOTAm-(Phen)3, two magnetoluminescent agents for dual imaging by MRI and confocal imaging are presented. The nanoparticles are characterized by high transverse and longitudinal relaxivities and long luminescence lifetimes ideal for time-gated spectroscopy.

Original languageEnglish (US)
Pages (from-to)2141-2147
Number of pages7
JournalEuropean Journal of Inorganic Chemistry
Issue number12
StatePublished - Apr 2012


  • Lanthanides
  • Luminescence
  • MRI
  • Nanoparticles
  • Time-gated spectroscopy


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