Nanoparticles are widely used as contrast and therapeutic agents. As such, imaging modalities that can accurately estimate their distribution in-vivo are actively sought. We present here our method Magneto Acoustic Tomography (MAT), which uses magnetomotive force due to a short pulsed magnetic field to induce ultrasound in the magnetic nanoparticle labeled tissue and estimates an image of the distribution of the nanoparticles in-vivo with ultrasound imaging resolution. In this study, we image the distribution of superparamagnetic iron oxide nanoparticles (IONP) using MAT method. In-vivo imaging was performed on live, nude mice with IONP injected into LNCaP tumors grown subcutaneously within the hind limb of the mice. Our experimental results indicate that the MAT method is capable of imaging the distribution of IONPs in-vivo. Therefore, MAT could become an imaging modality for high resolution reconstruction of MNP distribution in the body.
|Original language||English (US)|
|Number of pages||11|
|Journal||Nanomedicine: Nanotechnology, Biology, and Medicine|
|State||Published - Apr 1 2016|
Bibliographical noteFunding Information:
Funding: This work was supported in part by NIH EB014353 , EB017069 , EB006433 , and IEM Cancer Animal Core Lab .
The authors would like to thank Dr. Michael Ethridge for useful discussions with magnetic nanoparticles. Also, they would like to thank Katie R. Hurley (Department of Chemistry, University of Minnesota) for TEM preparation, imaging and measurements of the radii of EMG-308.
© 2015 Elsevier Inc.
- Magnetic nano particle
- Magneto acoustic tomography
- Magneto motive force