Magnetization transfer and adiabatic T1 MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis

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Abstract

Background: Diffuse abnormalities are known to occur within the brain tissue of multiple sclerosis (MS) patients thatis normal appearing on T1-weighted and T2-weighted magnetic resonance images.Objectives: With the goal of exploring the sensitivity of novel MRI parameters to detect such abnormalities, weimplemented an inversion-prepared magnetization transfer (MT) protocol and adiabatic T1ρ and T2ρrotating framerelaxation methods.Methods: Nine relapsing-remitting MS patients and seven healthy controls were recruited. Relaxation parameters weremeasured in a single slice just above the lateral ventricles and approximately parallel to the AC-PC line.Results: The MT ratio of regions encompassing the normal-appearing white matter (NAWM) was different in MSpatients as compared with controls (p = 0.043); however, the T1 measured during off-resonance irradiation (T1sat) wassubstantially more sensitive than the MT ratio for detecting differences between groups (p = 0.0006). Adiabatic T1ρwassignificantly prolonged in the NAWM of MS patents as compared to controls (by 6%, p = 0.026), while no differenceswere found among groups for T2ρ. No differences among groups were observed in the cortical gray matter for anyrelaxation parameter.Conclusions: The results suggest degenerative processes occurring in the NAWM of MS, likely not accompanied bysignificant abnormalities in iron content.

Original languageEnglish (US)
Pages (from-to)1066-1073
Number of pages8
JournalMultiple Sclerosis Journal
Volume20
Issue number8
DOIs
StatePublished - Jan 1 2014

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Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Patents
Lateral Ventricles
Magnetic Resonance Spectroscopy
Iron
Brain
White Matter
Gray Matter

Keywords

  • MRI
  • adiabatic pulses
  • inversion-prepared MT
  • multiple sclerosis
  • relapsing-remitting
  • rotating frame relaxation

Cite this

@article{f774e0989a594620983abc9c389f4e68,
title = "Magnetization transfer and adiabatic T1 MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis",
abstract = "Background: Diffuse abnormalities are known to occur within the brain tissue of multiple sclerosis (MS) patients thatis normal appearing on T1-weighted and T2-weighted magnetic resonance images.Objectives: With the goal of exploring the sensitivity of novel MRI parameters to detect such abnormalities, weimplemented an inversion-prepared magnetization transfer (MT) protocol and adiabatic T1ρ and T2ρrotating framerelaxation methods.Methods: Nine relapsing-remitting MS patients and seven healthy controls were recruited. Relaxation parameters weremeasured in a single slice just above the lateral ventricles and approximately parallel to the AC-PC line.Results: The MT ratio of regions encompassing the normal-appearing white matter (NAWM) was different in MSpatients as compared with controls (p = 0.043); however, the T1 measured during off-resonance irradiation (T1sat) wassubstantially more sensitive than the MT ratio for detecting differences between groups (p = 0.0006). Adiabatic T1ρwassignificantly prolonged in the NAWM of MS patents as compared to controls (by 6{\%}, p = 0.026), while no differenceswere found among groups for T2ρ. No differences among groups were observed in the cortical gray matter for anyrelaxation parameter.Conclusions: The results suggest degenerative processes occurring in the NAWM of MS, likely not accompanied bysignificant abnormalities in iron content.",
keywords = "MRI, adiabatic pulses, inversion-prepared MT, multiple sclerosis, relapsing-remitting, rotating frame relaxation",
author = "Silvia Mangia and Adam Carpenter and Tyan, {Andy E.} and Eberly, {Lynn E} and Michael Garwood and Shalom Michaeli",
year = "2014",
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TY - JOUR

T1 - Magnetization transfer and adiabatic T1 MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis

AU - Mangia, Silvia

AU - Carpenter, Adam

AU - Tyan, Andy E.

AU - Eberly, Lynn E

AU - Garwood, Michael

AU - Michaeli, Shalom

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Diffuse abnormalities are known to occur within the brain tissue of multiple sclerosis (MS) patients thatis normal appearing on T1-weighted and T2-weighted magnetic resonance images.Objectives: With the goal of exploring the sensitivity of novel MRI parameters to detect such abnormalities, weimplemented an inversion-prepared magnetization transfer (MT) protocol and adiabatic T1ρ and T2ρrotating framerelaxation methods.Methods: Nine relapsing-remitting MS patients and seven healthy controls were recruited. Relaxation parameters weremeasured in a single slice just above the lateral ventricles and approximately parallel to the AC-PC line.Results: The MT ratio of regions encompassing the normal-appearing white matter (NAWM) was different in MSpatients as compared with controls (p = 0.043); however, the T1 measured during off-resonance irradiation (T1sat) wassubstantially more sensitive than the MT ratio for detecting differences between groups (p = 0.0006). Adiabatic T1ρwassignificantly prolonged in the NAWM of MS patents as compared to controls (by 6%, p = 0.026), while no differenceswere found among groups for T2ρ. No differences among groups were observed in the cortical gray matter for anyrelaxation parameter.Conclusions: The results suggest degenerative processes occurring in the NAWM of MS, likely not accompanied bysignificant abnormalities in iron content.

AB - Background: Diffuse abnormalities are known to occur within the brain tissue of multiple sclerosis (MS) patients thatis normal appearing on T1-weighted and T2-weighted magnetic resonance images.Objectives: With the goal of exploring the sensitivity of novel MRI parameters to detect such abnormalities, weimplemented an inversion-prepared magnetization transfer (MT) protocol and adiabatic T1ρ and T2ρrotating framerelaxation methods.Methods: Nine relapsing-remitting MS patients and seven healthy controls were recruited. Relaxation parameters weremeasured in a single slice just above the lateral ventricles and approximately parallel to the AC-PC line.Results: The MT ratio of regions encompassing the normal-appearing white matter (NAWM) was different in MSpatients as compared with controls (p = 0.043); however, the T1 measured during off-resonance irradiation (T1sat) wassubstantially more sensitive than the MT ratio for detecting differences between groups (p = 0.0006). Adiabatic T1ρwassignificantly prolonged in the NAWM of MS patents as compared to controls (by 6%, p = 0.026), while no differenceswere found among groups for T2ρ. No differences among groups were observed in the cortical gray matter for anyrelaxation parameter.Conclusions: The results suggest degenerative processes occurring in the NAWM of MS, likely not accompanied bysignificant abnormalities in iron content.

KW - MRI

KW - adiabatic pulses

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KW - multiple sclerosis

KW - relapsing-remitting

KW - rotating frame relaxation

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